Journal of Gastrointestinal Surgery

, Volume 14, Issue 10, pp 1536–1546 | Cite as

One Hundred Thirty Resections for Pancreatic Neuroendocrine Tumor: Evaluating the Impact of Minimally Invasive and Parenchyma-Sparing Techniques

  • Joseph DiNorcia
  • Minna K. Lee
  • Patrick L. Reavey
  • Jeanine M. Genkinger
  • James A. Lee
  • Beth A. Schrope
  • John A. Chabot
  • John D. AllendorfEmail author
2010 SSAT Plenary Presentation



Increasingly, surgeons apply minimally invasive and parenchyma-sparing techniques to the management of pancreatic neuroendocrine tumor (PNET). The aim of this study was to evaluate the impact of these approaches on patient outcomes.


We retrospectively collected data on patients with PNET and compared perioperative and pathologic variables. Survival was analyzed using the Kaplan–Meier method. Factors influencing survival were evaluated using a Cox proportional hazards model.


One hundred thirty patients underwent resection for PNET. Traditional resections included 43 pancreaticoduodenectomies (PD), 38 open distal pancreatectomies (DP), and four total pancreatectomies. Minimally invasive and parenchyma-sparing resections included 25 laparoscopic DP, 11 central pancreatectomies, five enucleations, three partial pancreatectomies, and one laparoscopic-assisted PD. Compared to traditional resections, the minimally invasive and parenchyma-sparing resections had shorter hospital stays. By univariate analysis of neuroendocrine carcinoma, liver metastases and positive resection margins correlated with poor survival. There was an increase in minimally invasive or parenchyma-sparing resections over the study period with no differences in morbidity, mortality, or survival.


In this series, there has been a significant increase in minimally invasive and parenchyma-sparing techniques for PNET. This shift did not increase morbidity or compromise survival. In addition, minimally invasive and parenchyma-sparing operations yielded shorter hospital stays.


Pancreatic neuroendocrine tumor Pancreatectomy Minimally invasive Laparoscopic Parenchyma-sparing resection 



This work was supported by the I.W. Foundation, The Doris Duke Charitable Foundation, and an institutional Ruth L. Kirschstein National Research Service Award (T32 HL 007854-14).


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Copyright information

© The Society for Surgery of the Alimentary Tract 2010

Authors and Affiliations

  • Joseph DiNorcia
    • 1
  • Minna K. Lee
    • 1
  • Patrick L. Reavey
    • 1
  • Jeanine M. Genkinger
    • 2
  • James A. Lee
    • 1
  • Beth A. Schrope
    • 1
  • John A. Chabot
    • 1
  • John D. Allendorf
    • 1
    Email author
  1. 1.College of Physicians and Surgeons, Department of SurgeryColumbia UniversityNew YorkUSA
  2. 2.Mailman School of Public Health, Department of EpidemiologyColumbia UniversityNew YorkUSA

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