Journal of Gastrointestinal Surgery

, Volume 15, Issue 1, pp 101–109 | Cite as

Neuroendocrine Tumors of Meckel’s Diverticulum: Lessons from a Single Institution Study of Eight Cases

  • Gilles Poncet
  • Valérie Hervieu
  • Thomas Walter
  • Florian Lépinasse
  • Laurence Chardon
  • Frank Pilleul
  • Catherine Lombard-Bohas
  • Jean-Alain Chayvialle
  • Christian Partensky
  • Jean-Yves ScoazecEmail author
Original Article



Endocrine tumors of Meckel’s diverticulum are rare. Their clinical and pathological characteristics are not well known, making it difficult to assess the best strategy for therapeutic management.

Materials and Methods

Eight cases of endocrine tumors of Meckel’s diverticulum, submitted to surgical resection in our institution between 1977 and 2009, were studied. Clinical charts were reviewed; classification, grading, and staging were performed according to recent international recommendations. Five cases, including two associated with the carcinoid syndrome, were revealed by mesenteric mass or liver metastases; three cases were diagnosed incidentally at laparotomy or laparoscopy.


All cases presented as typical well-differentiated midgut endocrine tumors. Five cases were associated with mesenteric lymph node metastases; three presented with liver metastases. Seven cases were classified as well-differentiated endocrine carcinomas, one as well-differentiated endocrine tumor of benign behavior.


All tumors >1 cm, but one, had regional or distant disease. All patients had complete surgical resection of the primary. One patient deceased after 25 months; the others were alive after 12–101 months.


In conclusion, endocrine tumors of Meckel’s diverticulum are rarely symptomatic and often diagnosed at an advanced stage. All tumors measuring more than 1 cm in diameter must be resected according to oncological principles.


Neuroendocrine tumors Meckel’s diverticulum Surgery Pathology Carcinoid syndrome 


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Copyright information

© The Society for Surgery of the Alimentary Tract 2010

Authors and Affiliations

  • Gilles Poncet
    • 1
    • 2
  • Valérie Hervieu
    • 2
    • 3
    • 4
  • Thomas Walter
    • 1
    • 2
    • 4
  • Florian Lépinasse
    • 3
  • Laurence Chardon
    • 2
    • 5
  • Frank Pilleul
    • 4
    • 6
  • Catherine Lombard-Bohas
    • 1
  • Jean-Alain Chayvialle
    • 1
    • 4
  • Christian Partensky
    • 1
    • 4
  • Jean-Yves Scoazec
    • 2
    • 3
    • 4
    Email author
  1. 1.Hospices Civils de Lyon, Hôpital Edouard Herriot, Fédération des Spécialités DigestivesLyonFrance
  2. 2.INSERM, UMR S865, Faculté LaennecLyonFrance
  3. 3.Hospices Civils de Lyon, Hôpital Edouard Herriot, Service Central d’Anatomie et Cytologie PathologiquesLyonFrance
  4. 4.Université de Lyon, Université Lyon 1, VilleurbanneLyonFrance
  5. 5.Hospices Civils de Lyon, Hôpital Edouard Herriot, Fédération de BiochimieLyonFrance
  6. 6.Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Radiologie DigestiveLyonFrance

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