Sleeve Gastrectomy Provides a Better Control of Diabetes by Decreasing Ghrelin in the Diabetic Goto–Kakizaki Rats

  • Feng Li
  • Guangyong Zhang
  • Jianwei Liang
  • Xiangjiu Ding
  • Zhiqiang Cheng
  • Sanyuan Hu
Original Article

Abstract

Aim

Sleeve gastrectomy (SG) and modified duodenal jejunal bypass (MDJB) were compared as procedures for glucose control. We aim to form the initial conclusions with respect to the possibility of (1) whether gastric fundus exclusion is essential for the control of diabetes and (2) application as a low morbidity procedure.

Materials and Methods

SG and MDJB were performed on 10- to 12-week-old Goto–Kakizaki rats that spontaneously develop type 2 diabetes. Rats were observed for 36 weeks after surgery, and glucose, insulin, glucagons-like peptide-1 (GLP-1), glucose tolerate, insulin sensitivity, cholesterol, triglycerides, and free fatty acid levels were measured.

Results

Apart from distinct weight loss of SG and MDJB after 1 month compared with sham-operated rats (P < 0.001), SG showed strikingly improved blood glucose levels and significantly decreased Ghrelin secretion (P < 0.001). Furthermore, SG resulted in a shorter operative time (P < 0.01) and postoperative recovery time (P < 0.01) than MDJB group.

Conclusions

SG shows better control in terms of glucose tolerance and other measurements. This study provides direct evidence that SG possesses better improvement of diabetes by reduction of Ghrelin.

Keywords

Sleeve gastrectomy Modified duodenal jejunal bypass Glucagon-like peptide-1 Insulin 

Abbreviations

SG

Sleeve gastrectomy

GK

Goto–Kakizaki

MDJB

Modified duodenal jejunal bypass

OGTT

Oral glucose tolerance test

ITT

Insulin tolerance test

GLP-1

Glucagon-like peptide-1

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Copyright information

© The Society for Surgery of the Alimentary Tract 2009

Authors and Affiliations

  • Feng Li
    • 1
  • Guangyong Zhang
    • 1
  • Jianwei Liang
    • 1
  • Xiangjiu Ding
    • 1
  • Zhiqiang Cheng
    • 1
  • Sanyuan Hu
    • 1
  1. 1.Department of General SurgeryQilu Hospital of Shandong UniversityJinanPeople’s Republic of China

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