Journal of Gastrointestinal Surgery

, Volume 13, Issue 9, pp 1651–1658 | Cite as

Post-cholecystectomy Quality of Life: A Prospective Multicenter Cohort Study of Its Associations with Preoperative Functional Status and Patient Demographics

  • Hon-Yi Shi
  • King-Teh Lee
  • Hao-Hsien Lee
  • Yih-Huei Uen
  • Jinn-Tsong Tsai
  • Chong-Chi Chiu
Original Article



This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality of life (QOL).


This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments were interpreted by generalized estimating equation (GEE) before and after cholecystectomy.


The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time2) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time2, age, gender, preoperative GIQLI score, body mass index, and number of comorbidities.


The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative functional status and demographic characteristics.


SF-36 GIQLI Cholecystectomy Bootstrapping GEE 


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Copyright information

© The Society for Surgery of the Alimentary Tract 2009

Authors and Affiliations

  • Hon-Yi Shi
    • 1
  • King-Teh Lee
    • 1
    • 2
  • Hao-Hsien Lee
    • 3
  • Yih-Huei Uen
    • 3
  • Jinn-Tsong Tsai
    • 6
  • Chong-Chi Chiu
    • 3
    • 4
    • 5
  1. 1.Graduate Institute of Healthcare AdministrationKaohsiung Medical UniversityKaohsiungTaiwan
  2. 2.Division of Hepatobiliary Surgery, Department of SurgeryKaohsiung Medical University HospitalKaohsiungTaiwan
  3. 3.Department of General SurgeryChi Mei Medical CenterTainanTaiwan
  4. 4.Chia Nan University of Pharmacy and ScienceTainanTaiwan
  5. 5.Taipei Medical UniversityTaipeiTaiwan
  6. 6.Department of Computer ScienceNational Pingtung University of EducationPingtungTaiwan

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