Journal of Gastrointestinal Surgery

, Volume 12, Issue 10, pp 1738–1744

Use of Infliximab within 3 Months of Ileocolonic Resection is Associated with Adverse Postoperative Outcomes in Crohn’s Patients

  • Kweku A. Appau
  • Victor W. Fazio
  • Bo Shen
  • James M. Church
  • Bret Lashner
  • Feza Remzi
  • Aaron Brzezinski
  • Scott A. Strong
  • Jeffrey Hammel
  • Ravi P. Kiran
ssat plenary presentation

Abstract

Background

Few studies have evaluated preoperative infliximab use and postoperative outcomes in Crohn’s patients. Our aim was to evaluate 30-day postoperative outcomes for Crohn’s patients treated with infliximab within 3 months prior to ileocolonic resection.

Methods

The study is a retrospective evaluation of data for patients undergoing ileocolonic resection after 1998 from a prospective Crohn’s disease database. Patient characteristics and 30-day complications were compared for patients treated with infliximab within 3 months before surgery and an infliximab naïve group. The infliximab group was also compared with non-infliximab patients undergoing ileocolonic surgery before 1998.

Results

Sixty of 389 Crohn’s patients undergoing ileocolonic resection received infliximab. The infliximab and non-infliximab groups had similar characteristics, preoperative risk factors, and surgical procedure. However, steroid use was higher (p < 0.05) in the non-infliximab group while concurrent immunosuppressive use was higher (p < 0.001) in the infliximab group. Multivariate analysis showed infliximab use to be associated with 30-day postoperative readmission (p = 0.045), sepsis (p = 0.027), and intraabdominal abscess (p = 0.005). The presence of diverting stoma (n = 17) in the infliximab group was associated with lower risk of sepsis (0% vs. 27.9%, p = 0.013). Similar results were noted when the infliximab group was compared to the pre-infliximab patients.

Conclusions

Infliximab use within 3 months before surgery is associated with increased postoperative sepsis, abscess, and readmissions in Crohn’s patients. Diverting stoma may protect against these complications.

Keywords

Infliximab Crohn’s disease Ileocolonic resection Postoperative complications Abscess Sepsis Anastomotic leak Readmissions 

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Copyright information

© The Society for Surgery of the Alimentary Tract 2008

Authors and Affiliations

  • Kweku A. Appau
    • 1
  • Victor W. Fazio
    • 1
  • Bo Shen
    • 1
  • James M. Church
    • 1
  • Bret Lashner
    • 1
  • Feza Remzi
    • 1
  • Aaron Brzezinski
    • 1
  • Scott A. Strong
    • 1
  • Jeffrey Hammel
    • 1
  • Ravi P. Kiran
    • 1
  1. 1.The Cleveland Clinic FoundationClevelandUSA

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