Journal of Gastrointestinal Surgery

, Volume 12, Issue 1, pp 110–116

Long-Term Outcomes Following Liver Transplantation for Hepatic Hemangioendothelioma: The UNOS Experience from 1987 to 2005

  • Joel A. Rodriguez
  • Natasha S. Becker
  • Christine A. O’Mahony
  • John A. Goss
  • Thomas A. Aloia
Article

Abstract

Introduction

Hepatic hemangioendothelioma (HEH) is a vascular neoplasm with intermediate malignant potential. Outcomes after liver transplantation have only been reported as small, single-institution experiences. The purpose of this study was to evaluate patient and allograft survivals after liver transplantation in a large, multi-institutional cohort of patients with HEH.

Methods

Using the United Network for Organ Sharing (UNOS) database, we identified 110 patients with a diagnosis of HEH who underwent 126 transplants between 1987 and 2005. Patient and allograft survivals were calculated using Kaplan–Meier survival curves. Log rank tests were used to determine the influence of study variables on outcomes.

Results

Of the 110 transplanted patients, 75 patients (68%) were female, 80 patients (73%) were Caucasian, and the median age was 36 years old (23% < 4 y.o., 71% > 18 y.o.). The 30-day posttransplant mortality rate was 2.4%. At a median patient follow-up interval of 24 months, 1- and 5-year patient and allograft survivals were 80% and 64%, and 70% and 55%, respectively. Pretransplant medical status, but not age, was found to statistically correlate with patient survival.

Conclusion

These data indicate that survivals after transplantation for HEH are favorable. Given the propensity for recurrence after resection, these data support consideration of liver transplantation for all patients with significant intrahepatic tumor burden.

Keywords

Orthotopic liver transplantation Hemangioendothelioma Survival analysis 

Copyright information

© The Society for Surgery of the Alimentary Tract 2007

Authors and Affiliations

  • Joel A. Rodriguez
    • 1
  • Natasha S. Becker
    • 1
  • Christine A. O’Mahony
    • 1
  • John A. Goss
    • 1
  • Thomas A. Aloia
    • 1
  1. 1.Michael E. DeBakey Department of SurgeryBaylor College of MedicineHoustonUSA

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