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Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database

  • Juan LeiEmail author
  • Yi Wang
  • Zhuofei Bi
  • Shengneng Xue
  • Bing Ou
  • Kan Liu
Original Article
  • 49 Downloads

Abstract

Purpose

Intraoperative radiotherapy (IORT) has emerged as an alternative to whole-breast external beam radiotherapy (EBRT) for early breast cancer. This study aimed to investigate the risk factors for survival after IORT or whole-breast EBRT in breast cancer patients.

Materials and methods

Breast cancer patients undergoing IORT or whole-breast EBRT were included from the surveillance, epidemiology, and end results database. Risk factors for overall survival (OS) and cancer-specific survival (CSS) were identified by Cox proportional hazards regression analysis.

Results

The IORT and EBRT groups did not differ significantly in OS and CSS. T2 stage (tumor size > 2 cm) was associated with poorer OS (aHR 3.49, 95% CI 1.05–11.62, P = 0.042), whereas ER-positive tumors were associated with better OS (aHR 0.26, 95% CI 0.09–0.76, P = 0.014).

Conclusion

IORT was not inferior than EBRT considering the OS and CSS in the short-term follow-up of early breast cancer. It may be a reasonable alternative to EBRT for early breast cancer in select patients with favorable tumor size and receptor status, given the need for long-term monitoring of local control and radiation toxicity.

Keywords

Early stage breast cancer Intraoperative radiotherapy (IORT) Whole-breast external beam radiotherapy Prognosis Survival 

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Japan Radiological Society 2019

Authors and Affiliations

  1. 1.Department of Cardiology, Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  2. 2.Department of MathematicsCalifornia State University Dominguez HillsCarsonUSA
  3. 3.Department of Radiation OncologySun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  4. 4.Department of Ultrasound, Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  5. 5.Department of Endocrinology and Metabolism, Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China
  6. 6.Division of Cardiology, Heart and Vascular CenterUniversity of Iowa Hospital and ClinicsIowaUSA

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