Usefulness of histologic differences and perivascular infiltration for preoperative T staging of advanced gastric cancer using computed tomography
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This study aimed to determine whether histologic differences and perivascular infiltration are useful for clinical T staging of advanced gastric cancer (AGC).
Materials and methods
This retrospective study included 160 patients with pathologically confirmed AGC who had available preoperative stomach computed tomography (CT). Using stomach CT, they were classified according to standard T stage, histologic T stage, and perivascular T stage. Accuracy of each T stage criteria was analyzed. Perivascular infiltrations for the evaluation of prognosis were correlated with time to tumor progression by log-rank test.
There was a significant difference between the accuracies of the standard and histologic T stages (p < 0.001), whereas there was no significant difference between the standard and perivascular T stages (p = 0.07). In 121 patients who were pathologically confirmed as having T3 or T4a tumor, there was a significant difference between the standard and perivascular T stage (p < 0.001). In patients having T3 or T4a tumor, time to tumor progression of the negative perivascular infiltration subgroup was significantly longer than the positive subgroup.
Consideration of histologic differences and perivascular infiltration may be useful for clinical T staging of AGC.
KeywordsComputed tomography Gastric cancer Histology Perivascular infiltration Staging
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by JYK and W-SC. The first draft of the manuscript was written by JYK and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- 12.Choi JI, Joo I, Lee JM. State-of-the-art preoperative staging of gastric cancer by MDCT and magnetic resonance imaging. J Gastroenterol. 2014;20:4546–57.Google Scholar
- 17.Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A III. AJCC cancer staging manual. 7th ed. New York: Springer; 2009. p. 117–126.Google Scholar