Imaging findings of mixed connective tissue disease in children and adolescents: a case series

  • Sureyya Burcu GorkemEmail author
  • Andrea S. Doria
  • Shirley Tse
Pictorial Essay


Mixed connective tissue disease (MCTD) is a rare disease in children and adolescents which overlaps features of juvenile idiopathic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. We have provided an image-based approach for evaluation of MCTD in children and adolescents, outlying the most frequent imaging findings. This approach would aid imagers and clinicians to consider the diagnosis of this rare entity and be able to make an accurate list of differential diagnosis for complex rheumatologic diseases such as MCTD, thus facilitating the ultimate goal of early diagnosis and optimal management of affected children.


Mixed connective tissue disorder Children and adolescents Differential diagnosis Imaging Juvenile idiopathic arthritis Polymyositis/dermatomyositis Systemic lupus erythematosus Systemic sclerosis 



There is no funding used for this study.

Compliance with ethical standards

Conflict of interest

Authors declare that there is no conflict of interest.

Ethical statement

This study was approved by the local ethical committee of The Hospital for Sick Children.


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Copyright information

© Japan Radiological Society 2019

Authors and Affiliations

  1. 1.Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical ImagingUniversity of TorontoTorontoCanada
  2. 2.Department of Rheumatology, The Hospital for Sick Children, Department of Medical ImagingUniversity of TorontoTorontoCanada

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