Advertisement

Imaging findings of mixed connective tissue disease in children and adolescents: a case series

  • Sureyya Burcu GorkemEmail author
  • Andrea S. Doria
  • Shirley Tse
Pictorial Essay
  • 25 Downloads

Abstract

Mixed connective tissue disease (MCTD) is a rare disease in children and adolescents which overlaps features of juvenile idiopathic arthritis, polymyositis/dermatomyositis, systemic lupus erythematosus, and systemic sclerosis. We have provided an image-based approach for evaluation of MCTD in children and adolescents, outlying the most frequent imaging findings. This approach would aid imagers and clinicians to consider the diagnosis of this rare entity and be able to make an accurate list of differential diagnosis for complex rheumatologic diseases such as MCTD, thus facilitating the ultimate goal of early diagnosis and optimal management of affected children.

Keywords

Mixed connective tissue disorder Children and adolescents Differential diagnosis Imaging Juvenile idiopathic arthritis Polymyositis/dermatomyositis Systemic lupus erythematosus Systemic sclerosis 

Notes

Funding

There is no funding used for this study.

Compliance with ethical standards

Conflict of interest

Authors declare that there is no conflict of interest.

Ethical statement

This study was approved by the local ethical committee of The Hospital for Sick Children.

References

  1. 1.
    Petty RE, Lindsley CB, Laxer RM. The textbook of pediatric rheumatology. 7th ed. Philadelphia, PA: Elsevier; 2015. p. 418–20.Google Scholar
  2. 2.
    Berard RA, Laxer RM. Pediatric mixed connective tissue disease. Curr Rheumatol Rep. 2016;18:28.CrossRefGoogle Scholar
  3. 3.
    Kahn MF, Appelboom T. Syndrome de Sharp. In: Kahn MF, Peltier AP, Mayer O, Piette JC, editors. Les maladies systemiques. 3rd ed. Paris: Flammarion; 1991. p. 545–56.Google Scholar
  4. 4.
    Sharp GC. In: Kasukawa R, Sharp GC, editors. Mixed connective tissue diseases and anti-nuclear antibodies. Amsterdam: Excerpta Medica; 1987. p. 23–32.Google Scholar
  5. 5.
    Alarcon-Segovia D, Villarreal M. In: Kasukawa R, Sharp GC, editors. Mixed connective tissue disease and anti-nuclear anti-bodies. Amsterdam: Excerpta Medica; 1987. p. 33–40.Google Scholar
  6. 6.
    Amigues JM, Cantagrel A, Abbal M, Mazieres B. Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. Autoimmunity Group of the Hospitals of Toulouse. J Rheumatol. 1996;23:2055–62.Google Scholar
  7. 7.
    Aaløkken TM, Lilleby V, Søyseth V, Mynarek G, Pripp AH, Johansen B, Førre O, Kolbenstvedt A. Chest abnormalities in juvenile-onset mixed connective tissue disease: assessment with high-resolution computed tomography and pulmonary function tests. Acta Radiol. 2009;50:430–6.CrossRefGoogle Scholar
  8. 8.
    Hamoir B, Giroux M, Outteryck O, et al. Mixed connective tissue disease presenting as trigeminal neuropathy. Acta Neurol Belg. 2014;114:245–6.CrossRefGoogle Scholar
  9. 9.
    Gal Y, Twig G, Mozes O, Greenberg G, Hoffmann C, Shoenfeld Y. Central nervous system involvement in systemic lupus erythematosus: an imaging challenge. Isr Med Assoc J. 2013;15:382–6.Google Scholar

Copyright information

© Japan Radiological Society 2019

Authors and Affiliations

  1. 1.Department of Diagnostic Imaging, The Hospital for Sick Children, Department of Medical ImagingUniversity of TorontoTorontoCanada
  2. 2.Department of Rheumatology, The Hospital for Sick Children, Department of Medical ImagingUniversity of TorontoTorontoCanada

Personalised recommendations