Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney disease

  • Hideo GobaraEmail author
  • Atsuhiro Nakatsuka
  • Kanichiro Shimizu
  • Takashi Yamanaka
  • Yusuke Matsui
  • Toshihiro Iguchi
  • Takao Hiraki
  • Koichiro Yamakado
Original Article



To evaluate the safety and efficacy of cryoablation for renal cell carcinoma (RCC) in patients with stage 4 or 5 non-dialysis chronic kidney disease (CKD).

Materials and methods

This retrospective multicenter study included patients with maximum tumor diameter ≤ 4 cm, estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2, in whom cryoablation was performed percutaneously with curative intent between July 2011 and May 2016.


Of 541 patients who underwent renal tumor cryoablation, 17 (3.1%; 4 women, 13 men; mean age 70.1 ± 10.6 years) with stage 4 or 5 non-dialysis CKD were included in this study. The pre-cryoablation eGFR was 22.5 ± 6.3 ml/min/1.73 m2. The mean tumor diameter was 2.8 ± 0.7 cm. No Grade 3 or higher adverse events occurred post-cryoablation. The eGFR at each time point was significantly lower than that before treatment. One patient required hemodialysis initiation at 21 months post-procedure. None of the patients showed residual RCC at their last follow-up.


Cryoablation of RCC is safe in patients with stage 4 or 5 non-dialysis CKD and yields treatment results comparable to those in patients without CKD. This treatment could be completed without the early initiation of hemodialysis after the procedure.


Chronic kidney disease Cryoablation Renal cell carcinoma Kidney Stage 4 



Nothing to disclose.

Compliance with ethical standards

Conflict of interest

Hideo Gobara and Takao Hiraki received funding from Okayama Prefecture, JPSS and AMED. Other authors have no conflict of interest to declare.

Ethical statement

Each institutional review board approved this retrospective multicenter study and waived the requirement for obtaining informed consent to use the patients’ medical data. All procedures performed were in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.


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Copyright information

© Japan Radiological Society 2019

Authors and Affiliations

  1. 1.Department of RadiologyOkayama University Medical SchoolOkayamaJapan
  2. 2.Department of Interventional RadiologyMie University HospitalTsuJapan
  3. 3.Department of RadiologyThe Jikei University School of Medicine, Kashiwa HospitalKashiwaJapan
  4. 4.Department of RadiologyThe Hospital of Hyogo College of MedicineNishinomiyaJapan

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