Computed tomographic colonography with a reduced dose of laxative using a novel barium sulfate contrast agent in Japan
- 26 Downloads
To test the tagging efficacy, patient acceptability, and accuracy of computed tomographic colonography (CTC) with a reduced dose of laxative using a novel barium sulfate (BaSO4) contrast agent.
Materials and methods
CTC followed by optical colonoscopy (OC) was performed on 73 patients with positive results in fecal occult blood tests. They were administrated a BaSO4 suspension and a magnesium citrate solution for bowel preparation. Patients completed a questionnaire about the acceptability of bowel preparation. Tagging efficacy was estimated using a novel categorization system, which classified all segments into 8 categories. The accuracy of detecting protruded lesions ≥ 6 mm was calculated from the comparison of CTC and OC results, using the latter as a reference standard.
Tagging efficacy was good in 77.3% of colonic segments where residue was observed. The acceptability of bowel preparation for CTC was significantly higher than that for OC. The sensitivity, specificity, and positive and negative predictive values were 0.778, 0.945, 0.824, and 0.929, respectively. All lesions ≥ 7 mm were successfully detected by CTC.
CTC with a reduced dose of laxative using a novel BaSO4 contrast agent has a favorable tagging efficacy, patient acceptability, and accuracy.
KeywordsComputed tomographic colonography (CTC) Barium sulfate Accuracy Patient acceptance Tagging efficacy
The scientific guarantor of this publication is K. Mitsuzaki, MD, PhD. This study was funded by Fushimi Pharmaceutical Co., Ltd. for the approval of a pharmaceutical product, and conducted in compliance with GCP (ICH-G6). Akira Yoshino of Fushimi Pharmaceutical Co., Ltd. conducted the statistical analysis.
This study was funded by Fushimi Pharmaceutical Co., Ltd. for the approval of a pharmaceutical product, and conducted in compliance with GCP (ICH-G6).
Compliance with ethical standards
Conflict of interest
All authors of this manuscript declare no relationship with any companies.
Research ethics and patient consent
Saiseikai Kumamoto Hospital Institutional Review Board approved this study (CTC-2310/P301). Written informed consent was obtained from all patients in this study.
- 1.Vining DJ, Gelfand DW, Bechtold RE, Scharling ES, Grishaw EK, Shifrin RY. Technical feasibility of colon imaging with helical CT and virtual reality. AJR Am J Roentgenol. 1994;162:S104.Google Scholar
- 17.Stoop EM, de Haan MC, de Wijkerslooth TR, Bossuyt PM, van Ballegooijen M, van de Vijver MJ, et al. Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial. Lancet Oncol. 2012;13:55–64.CrossRefGoogle Scholar
- 21.Jensch S, Bipat S, Peringa J, de Vries AH, Heutinck A, Dekker E, et al. CT colonography with limited bowel preparation: prospective assessment of patient experience and preference in comparison to optical colonoscopy with cathartic bowel preparation. Eur Radiol. 2010;20:146–56.CrossRefGoogle Scholar