Japanese Journal of Radiology

, Volume 37, Issue 1, pp 88–94 | Cite as

Hilar and mediastinal sarcoid-like reaction after the treatment of malignant tumors: imaging features and natural course on 18F-FDG-PET/CT

  • Yo Kaneko
  • Hiroki KatoEmail author
  • Masayuki Matsuo
Original Article



This study aimed to assess the imaging features and natural course of hilar and mediastinal sarcoid-like reaction on 18F-fluorodeoxyglucose (FDG) PET/CT after the treatment of malignancies.


Sixteen patients with the appearance of sarcoid-like reaction seen on 18F-FDG-PET/CT after treatment were included. Hilar and mediastinal lymph node metastases were pathologically or clinically ruled out. Posttreatment 18F-FDG-PET/CT imaging features were assessed.


The maximum standardized uptake values of sarcoid-like reaction were 3.8–13.6 (mean 6.8). FDG uptake of hilar nodes was symmetrical in 12 (75%) patients and asymmetrical in 4 (25%). The time interval between the initiation of therapy and appearance of sarcoid-like reaction was 9–86 months (median 27.1 months). Among 14 patients who underwent further follow-up using 18F-FDG-PET/CT, sarcoid-like reaction regressed in 11 (79%) patients and did not regress in 3 (21%) patients. The time interval between the appearance of sarcoid-like reaction and its regression was 3–80 months (median, 8.5 months).


After the treatment of malignancies, benign sarcoid-like reaction was rarely observed during follow-up. Although sarcoid-like reaction appeared a long time after the treatment of malignancies, it frequently and spontaneously regressed in a relatively short period of time.


PET Sarcoid-like reaction Sarcoidosis Malignancy 



The authors declare that there is no funding.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

The authors declare that they preserve ethical standards.


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Copyright information

© Japan Radiological Society 2018

Authors and Affiliations

  1. 1.Department of RadiologyGifu University School of MedicineGifuJapan

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