Evaluation of coronary artery variations using dual-source coronary computed tomography angiography in neonates with transposition of the great arteries
The purpose of this study was to investigate whether the origins and courses of the coronary arteries could be better assessed using ECG-gated dual-source computed tomography (CT) than with echocardiography in neonates with transposition of the great arteries (TGA).
A total of 17 neonates within 14 days old who underwent both echocardiography and retrospective ECG-gated coronary CT angiography were retrospectively reviewed. The patients were sedated and intubated during CT examinations, and CT images were obtained with a breath-hold. CT images were reconstructed by multiple cardiac phases, and the coronary artery assessment was performed in the most static phase. Coronary anomalies were classified by Shaher’s classification and validated by surgical findings.
CT correctly classified 16 of 17 cases (Shaher type 1: 7, type 2: 4, type 9: 3, type 3: 1, type 4: 2), whereas echocardiography classified only 8 of 17 cases correctly. Dual-source CT had a significantly higher diagnostic ability than echocardiography (p = 0.0078).
Dual-source coronary CT angiography has a higher diagnostic ability than echocardiography in the assessment of the origins and courses of the coronary arteries in neonates with TGA.
KeywordsTransposition of the great arteries Coronary anomalies Cardiac CT Neonate
Transposition of the great arteries
Congenital heart disease
Arterial switch operation
Multi-detector row computed tomography
Volume CT dose index
Left circumflex artery
Right coronary artery
Left anterior descending artery
This work was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI (17K16452).
Compliance with ethical standards
Conflict of interest
Yamasaki Y: Bayer Healthcare Japan, Modest, Research Grant; Philips Electronics Japan, Modest, Research Grant. Other authors declare that they have no conflict of interest.
Institutional Review Board approval at Fukuoka Children’s Hospital was obtained.
Written informed consent was waived due to the retrospective nature of the research.
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