Advertisement

Japanese Journal of Radiology

, Volume 34, Issue 6, pp 400–408 | Cite as

Imaging of metastases from breast cancer to uncommon sites: a pictorial review

  • Masafumi ToguchiEmail author
  • Mitsuru Matsuki
  • Isao Numoto
  • Masakatsu Tsurusaki
  • Izumi Imaoka
  • Kazunari Ishii
  • Rikiya Yamashita
  • Yuki Inada
  • Shuichi Monzawa
  • Hisato Kobayashi
  • Takamichi Murakami
Pictorial Essay

Abstract

There are three types of breast cancer recurrence which can occur after initial treatment: local, regional, and distant. Distant metastases are more frequent than local and regional recurrences. It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer. Although the common distant metastases are bone, lung and liver, breast cancer has the potential to metastasize to almost any region of the body. Early detection and treatment of distant metastases improves the prognosis, therefore radiologists and clinicians should recognize the possibility of metastasis from breast cancer and grasp the imaging characteristics. In this report, we demonstrate the imaging characteristics of metastases from breast cancer to uncommon sites.

Keywords

Breast cancer Metastasis CT MRI 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Matsuda A, Matsuda T, Shibata A, Katanoda K, Sobue T, Nishimoto H, et al. Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. Jpn J Clin Oncol. 2013;44:388–96.CrossRefGoogle Scholar
  2. 2.
    Chikarmane SA, Tirumani SH, Howard SA, Jagannathan JP, DiPiro PJ. Metastatic patterns of breast cancer subtypes: what radiologists should know in the era of personalized cancer medicine. Clin Radiol. 2015;70(1):1–10.CrossRefPubMedGoogle Scholar
  3. 3.
    Engstrøm MJ, Opdahl S, Vatten LJ, Haugen OA, Bofin AM. Invasive lobular breast cancer: the prognostic impact of histopathological grade, E-cadherin and molecular subtypes. Histopathology. 2015;66:409–19.CrossRefPubMedGoogle Scholar
  4. 4.
    Laigle-Donadey F, Taillibert S, Mokhtari K, Hildebrand J, Delattre JY. Dural metastases. J Neuro-oncol. 2005;75:57–61.CrossRefGoogle Scholar
  5. 5.
    Magalhães JF, Bacchin RP, Costa PS, Alves GM, Fraige Filho F, Stella LC. Breast cancer metastasis to the pituitary gland. Arq Bras Endocrinol Metabol. 2014;58:869–72.CrossRefPubMedGoogle Scholar
  6. 6.
    Rykken JB, Diehn FE, Hunt CH, Schwartz KM, Eckel LJ, Wood CP, et al. Intramedullary spinal cord metastases: MRI and relevant clinical features from a 13-year institutional case series. AJNR Am J Neuroradiol. 2013;34:2043–9.CrossRefPubMedGoogle Scholar
  7. 7.
    Dieing A, Schulz CO, Schmid P, Roever AC, Lehenbauer-Dehm S, Jehn C, et al. Orbital metastases in breast cancer: report of two cases and review of the literature. J Cancer Res Clin Oncol. 2004;130:745–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Wittenberg KH, Adkins MC. MR imaging of nontraumatic brachial plexopathies: frequency and spectrum of findings. RadioGraphics. 2000;20:1023–32.CrossRefPubMedGoogle Scholar
  9. 9.
    Kiryu T, Hoshi H, Matsui E, Iwata H, Kokubo M, Shimokawa K, et al. Endotracheal/endobronchial metastases: clinicopathologic study with special reference to developmental modes. Chest. 2001;119:768–75.CrossRefPubMedGoogle Scholar
  10. 10.
    Ambroggi M, Stroppa EM, Mordenti P, Biasini C, Zangrandi A, Michieletti E, et al. Metastatic breast cancer to the gastrointestinal tract: report of five cases and review of the literature. Int J Breast Cancer. 2012;. doi: 10.1155/2012/439023.PubMedPubMedCentralGoogle Scholar
  11. 11.
    Bezpalko K, Mohamed MA, Mercer L, McCann M, Elghawy K, Wilson K, et al. Concomitant endometrial and gallbladder metastasis in advanced multiple metastatic invasive lobular carcinoma of the breast: a rare case report. Int J Surg Case Rep. 2015;14:141–5.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Elri T, Aras M, Salihoglu YS, Cabuk M. Splenic metastasis of breast cancer: a rare metastatic site depicted on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography. Indian J Nucl Med. 2015;30(4):369–70.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Tanaka YO, Okada S, Satoh T, Matsumoto K, Oki A, Saida T, et al. Diversity in size and signal intensity in multilocular cystic ovarian masses: new parameters for distinguishing metastatic from primary mucinous ovarian neoplasms. J Magn Reson Imaging. 2013;38:794–801.CrossRefPubMedGoogle Scholar
  14. 14.
    Komeda S, Furukawa N, Kasai T, Washida A, Kobayashi H. Uterine metastasis of lobular breast cancer during adjuvant letrozole therapy. J Obstet Gynaecol. 2013;33:99–101.CrossRefPubMedGoogle Scholar
  15. 15.
    Miyamoto M, Akagawa S, Tamura A, Suzuki J, Masuda K, Hebisawa A, et al. Nihon Kokyuki Gakkai zasshi. 2012;1(6):531–5.Google Scholar
  16. 16.
    Nazareno J, Taves D, Preiksaitis HG. Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature. World J Gastroenterol. 2006;12(38):6219–24.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Gollub MJ, Schwartz MB, Shia J. Scirrhous metastases to the gastrointestinal tract at CT: the malignant target sign. AJR Am J Roentgenol. 2009;192:936–40.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Di Bonito L, Patriarca S, Alberico S. Breast carcinoma metastasizing to the uterus. Eur J Gynaecol Oncol. 1985;6:211–7.PubMedGoogle Scholar
  19. 19.
    Piura B, Yanai-Inbar I, Rabinovich A, Zalmanov S, Goldstein J. Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol. 1999;83:57–61.CrossRefPubMedGoogle Scholar
  20. 20.
    Kumar NB, Hart WR. Metastases to the uterine corpus from extragenital cancers. A clinicopathologic study of 63 cases. Cancer. 1982;50:2163–9.CrossRefPubMedGoogle Scholar

Copyright information

© Japan Radiological Society 2016

Authors and Affiliations

  • Masafumi Toguchi
    • 1
    Email author
  • Mitsuru Matsuki
    • 1
  • Isao Numoto
    • 1
  • Masakatsu Tsurusaki
    • 1
  • Izumi Imaoka
    • 1
  • Kazunari Ishii
    • 1
  • Rikiya Yamashita
    • 2
  • Yuki Inada
    • 3
  • Shuichi Monzawa
    • 4
  • Hisato Kobayashi
    • 5
  • Takamichi Murakami
    • 1
  1. 1.Department of RadiologyKindai University Faculty of MedicineOsaka-SayamaJapan
  2. 2.Department of RadiologyKyoto University HospitalKyotoJapan
  3. 3.Department of RadiologyOsaka Medical CollegeTakatsukiJapan
  4. 4.Department of Diagnostic RadiologyShinko HospitalKobeJapan
  5. 5.Department of RadiologyOtsu Red Cross HospitalOtsuJapan

Personalised recommendations