Advertisement

Japanese Journal of Radiology

, Volume 34, Issue 4, pp 307–311 | Cite as

A case of tubulocystic carcinoma of the kidney with aggressive features

  • Yoko Maeda
  • Keisuke Goto
  • Yukiko HondaEmail author
  • Naoto Kuroda
  • Kazuhiro Sentani
  • Wataru Yasui
  • Tetsutaro Hayashi
  • Jun Teishima
  • Akio Matsubara
  • Yuko Nakamura
  • Naoyuki Toyota
  • Makoto Iida
  • Kazuo Awai
Case Report

Abstract

Tubulocystic carcinoma of the kidney is rare and typically indolent. Our case involved an aggressive tubulocystic carcinoma as well as the radiological confirmation of its relation to papillary renal cell carcinoma. A 46-year-old male presented with renal multiloculated cysts with a solid part. On computed tomography and magnetic resonance imaging, the solid part showed the characteristics of papillary renal cell carcinoma. Contrast enhancement of the solid part was fluffy and sparse because of the coexistence of cysts. Perirenal fat invasion resulted in exophytic cysts, and renal-hilar cystic lymph node metastasis existed. The histopathological diagnosis was tubulocystic carcinoma associated with areas of papillary renal cell carcinoma and poorly differentiated carcinoma with metastasis. Our case suggests that the solid part enhancement of tubulocystic carcinoma tends to be fluffy and sparse, and exophytic cysts and cystic lymph nodes may show radiologically aggressive findings.

Keywords

Tubulocystic carcinoma Kidney Aggressive CT MRI 

Abbreviations

TCK

Tubulocystic carcinoma of the kidney

CT

Computed tomography

MRI

Magnetic resonance imaging

pRCC

Papillary renal cell carcinoma

Notes

Acknowledgments

The authors thank Dr. Toru Higaki (Department of Diagnostic Radiology, Institute of Biomedical and Health Sciences, Hiroshima University) for technical assistant.

Compliance with ethical standards

Information concerning grants

The authors state that this work has not received any funding.

Conflict of interest

The authors indicated no potential conflicts of interest.

Informed consent

Informed consent was obtained.

References

  1. 1.
    Cornelis F, Helenon O, Correas JM, Lemaitre L, Andre M, Meuwly JY, et al. Tubulocystic renal cell carcinoma: a new radiological entity. Eur Radiol. 2015. [Epub ahead of print].Google Scholar
  2. 2.
    MacLennan GT, Bostwick DG. Tubulocystic carcinoma, mucinous tubular and spindle cell carcinoma, and other recently described rare renal tumors. Clin Lab Med. 2005;25(2):393–416.CrossRefPubMedGoogle Scholar
  3. 3.
    Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, et al. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013;37(10):1469–89.CrossRefPubMedGoogle Scholar
  4. 4.
    Kuroda N, Matsumoto H, Ohe C, Mikami S, Nagashima Y, Inoue K, et al. Review of tubulocystic carcinoma of the kidney with focus on clinical and pathobiological aspects. Pol J Pathol. 2013;64(4):233–7.CrossRefPubMedGoogle Scholar
  5. 5.
    Yang XJ, Zhou M, Hes O, Shen S, Li R, Lopez J, et al. Tubulocystic carcinoma of the kidney: clinicopathologic and molecular characterization. Am J Surg Pathol. 2008;32(2):177–87.CrossRefPubMedGoogle Scholar
  6. 6.
    Amin MB, MacLennan GT, Gupta R, Grignon D, Paraf F, Vieillefond A, et al. Tubulocystic carcinoma of the kidney: clinicopathologic analysis of 31 cases of a distinctive rare subtype of renal cell carcinoma. Am J Surg Pathol. 2009;33(3):384–92.CrossRefPubMedGoogle Scholar
  7. 7.
    Hora M, Urge T, Eret V, Stransky P, Klecka J, Kreuzberg B, et al. Tubulocystic renal carcinoma: a clinical perspective. World J Urol. 2011;29(3):349–54.CrossRefPubMedGoogle Scholar
  8. 8.
    Al-Hussain TO, Cheng L, Zhang S, Epstein JI. Tubulocystic carcinoma of the kidney with poorly differentiated foci: a series of 3 cases with fluorescence in situ hybridization analysis. Hum Pathol. 2013;44(7):1406–11.CrossRefPubMedGoogle Scholar
  9. 9.
    Zhou M, Yang XJ, Lopez JI, Shah RB, Hes O, Shen SS, et al. Renal tubulocystic carcinoma is closely related to papillary renal cell carcinoma: implications for pathologic classification. Am J Surg Pathol. 2009;33(12):1840–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Nagashima Y, Kuroda N, Yao M. Transition of organizational category on renal cancer. Jpn J Clin Oncol. 2013;43(3):233–42.CrossRefPubMedGoogle Scholar
  11. 11.
    Kuroda N, Tanaka A, Ohe C, Nagashima Y. Recent advances of immunohistochemistry for diagnosis of renal tumors. Pathol Int. 2013;63(8):381–90.CrossRefPubMedGoogle Scholar
  12. 12.
    Shinmoto H, Yuasa Y, Tanimoto A, Narimatsu Y, Jinzaki M, Hiramatsu K, et al. Small renal cell carcinoma: MRI with pathologic correlation. J Magn Reson Imaging. 1998;8(3):690–4.CrossRefPubMedGoogle Scholar
  13. 13.
    Jinzaki M, Tanimoto A, Mukai M, Ikeda E, Kobayashi S, Yuasa Y, et al. Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis. J Comput Assist Tomogr. 2000;24(6):835–42.CrossRefPubMedGoogle Scholar
  14. 14.
    Oliva MR, Glickman JN, Zou KH, Teo SY, Mortele KJ, Rocha MS, et al. Renal cell carcinoma: T1 and T2 signal intensity characteristics of papillary and clear cell types correlated with pathology. AJR Am J Roentgenol. 2009;192(6):1524–30.CrossRefPubMedGoogle Scholar

Copyright information

© Japan Radiological Society 2016

Authors and Affiliations

  • Yoko Maeda
    • 1
    • 6
  • Keisuke Goto
    • 2
    • 4
  • Yukiko Honda
    • 1
    Email author
  • Naoto Kuroda
    • 3
  • Kazuhiro Sentani
    • 2
  • Wataru Yasui
    • 2
  • Tetsutaro Hayashi
    • 4
  • Jun Teishima
    • 4
  • Akio Matsubara
    • 4
  • Yuko Nakamura
    • 1
    • 5
  • Naoyuki Toyota
    • 6
  • Makoto Iida
    • 1
  • Kazuo Awai
    • 1
  1. 1.Department of Diagnostic Radiology, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of Molecular Pathology, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  3. 3.Department of Diagnostic PathologyKochi Red Cross HospitalKochiJapan
  4. 4.Department of Urology, Institute of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan
  5. 5.Molecular Imaging Program, Center for Cancer Research, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  6. 6.Department of Diagnostic RadiologyNational Hospital Organization Kure Medical CenterHiroshimaJapan

Personalised recommendations