Japanese Journal of Radiology

, Volume 32, Issue 2, pp 98–104 | Cite as

Diffusional kurtosis imaging analysis in patients with hypertension

  • Keigo ShimojiEmail author
  • Takanori Uka
  • Yoshifumi Tamura
  • Mariko Yoshida
  • Koji Kamagata
  • Masaaki Hori
  • Yumiko Motoi
  • Hirotaka Watada
  • Ryuzo Kawamori
  • Shigeki Aoki
Original Article



Hypertension is associated with substantial morbidity in Japan. The aim of this work was to evaluate whether hypertension is associated with white matter microstructural changes by using diffusional kurtosis imaging (DKI).


We explored the regional patterns of white matter alteration in 15 hypertensive middle-aged male participants and 11 normotensive controls by using DKI-based whole-brain analysis. In addition, we investigated whether the observed white matter microstructural changes were related to systolic or diastolic blood pressure by using Pearson’s correlation coefficient analysis.


Mean diffusional kurtosis (MDK) values were significantly higher in hypertensive participants than in normotensive participants (P < 0.05; family-wise error correction for multiple comparisons), indicating widespread microstructural changes in white matter. Moreover, we noted a statistically significant positive correlation between systolic and diastolic blood pressure and MDK values of the whole brain.


Our study suggests that microstructural white matter changes occur in middle-aged men with hypertension, even before the onset of cerebrovascular disease. Thus, DKI might be used as a screening tool for risk of cerebrovascular disease. This highlights the need to further elucidate the relationship between hypertension and DKI of the brain.


Hypertension Cerebrum Diffusional kurtosis imaging 



This study was supported in part by a High Technology Research Center Grant from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT). The research was also supported in part by a MEXT Grant-in-Aid for Scientific Research on Innovative Areas (Comprehensive Brain Science Network), and by a MEXT KAKENHI Grant (Number 25861126).


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Copyright information

© Japan Radiological Society 2014

Authors and Affiliations

  • Keigo Shimoji
    • 1
    • 2
    Email author
  • Takanori Uka
    • 3
  • Yoshifumi Tamura
    • 4
    • 5
  • Mariko Yoshida
    • 2
  • Koji Kamagata
    • 2
  • Masaaki Hori
    • 2
  • Yumiko Motoi
    • 6
  • Hirotaka Watada
    • 4
    • 5
  • Ryuzo Kawamori
    • 4
    • 5
  • Shigeki Aoki
    • 2
  1. 1.Department of RadiologyNational Center of Neurology and Psychiatry HospitalTokyoJapan
  2. 2.Department of RadiologyJuntendo University Graduate School of MedicineTokyoJapan
  3. 3.Department of NeurophysiologyJuntendo University Graduate School of MedicineTokyoJapan
  4. 4.Department of Medicine, Metabolism, and EndocrinologyJuntendo University Graduate School of MedicineTokyoJapan
  5. 5.Sportology Center, Juntendo University Graduate School of MedicineTokyoJapan
  6. 6.Department of Diagnosis, Prevention and Treatment of DementiaJuntendo University Graduate School of MedicineTokyoJapan

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