Japanese Journal of Radiology

, Volume 32, Issue 2, pp 80–89 | Cite as

Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy

  • Masamitsu Hatakenaka
  • Katsumasa Nakamura
  • Hidetake Yabuuchi
  • Yoshiyuki Shioyama
  • Yoshio Matsuo
  • Takeshi Kamitani
  • Masato Yonezawa
  • Takashi Yoshiura
  • Torahiko Nakashima
  • Mitsuru Mori
  • Hiroshi Honda
Original Article



To evaluate the correlation between apparent diffusion coefficient (ADC) and prognosis in head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy.

Materials and methods

We retrospectively studied 41 patients (38 male and 3 female, ages 37–85 years) diagnosed with HNSCC (14 oropharynx, 22 hypopharynx, 4 larynx, 1 oral cavity) and treated with radiotherapy, with radiation dose to gross tumor volume over 60 Gy. The association between age, gender, performance status, tumor location, T stage, N stage, stage, dose, overall treatment time, treatment method, adjuvant therapy, or ADC and prognosis was analyzed using a Cox proportional hazard test.


ADC calculated with b-values of 300, 500, 750, and 1,000 s/mm2 (ADC 300–1,000) alone showed a significant correlation with all of the analyses (p = 0.022 for local control, p = 0.0109 for regional control, p = 0.0041 for disease-free survival, and p = 0.0014 for overall survival). ADC calculated with b-values of 0, 100, and 200 s/mm2 (ADC 0–200) showed a significant correlation with overall survival (p = 0.0012). N stage showed a significant correlation with regional control (p = 0.0241). Performance status showed significant association with local control (p = 0.0459), disease-free survival (p = 0.023), and overall survival (p = 0.0151), respectively.


ADC is an independent predictor of prognosis in HNSCC treated with radiotherapy.


Apparent diffusion coefficient Bystander effect Head and neck cancer Prognosis Radiotherapy 


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Japan Radiological Society 2014

Authors and Affiliations

  • Masamitsu Hatakenaka
    • 1
  • Katsumasa Nakamura
    • 2
  • Hidetake Yabuuchi
    • 3
  • Yoshiyuki Shioyama
    • 4
  • Yoshio Matsuo
    • 2
  • Takeshi Kamitani
    • 2
  • Masato Yonezawa
    • 2
  • Takashi Yoshiura
    • 2
  • Torahiko Nakashima
    • 5
  • Mitsuru Mori
    • 6
  • Hiroshi Honda
    • 2
  1. 1.Department of Diagnostic Radiology, School of MedicineSapporo Medical UniversitySapporoJapan
  2. 2.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of Health Sciences, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  4. 4.Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  5. 5.Department of Otorhinolaryngology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  6. 6.Department of Public Health, School of MedicineSapporo Medical UniversitySapporoJapan

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