Skip to main content

Advertisement

SpringerLink
Log in

Fibrolamellar hepatocellular carcinoma with biliary tumor thrombus: an unreported association

  • Case Report
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Fibrolamellar hepatocellular carcinoma (FHCC) is a rare malignant tumor of hepatocyte origin occurring earlier in life than typical hepatocellular carcinoma (HCC). We describe a distinctive case of FHCC with biliary tumor thrombus (BTT) in a 25-year-old Caucasian patient, pointing out the imaging features supported by histopathology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Craig JR, Peters RL, Edmonson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinicopathologic features. Cancer. 1980;46:372–9.

    Article  PubMed  CAS  Google Scholar 

  2. Berman MM, Libbey NP, Foster JH. Hepatocellular carcinoma: polygonal cell type with fibrous stroma–an atypical variant with a favorable prognosis. Cancer. 1980;46:1448–55.

    Article  PubMed  CAS  Google Scholar 

  3. McLarney JK, Rucker PT, Bender GN, Goodman ZD, Kashitani N, Ros PR. Fibrolamellar carcinoma of the liver: radiologic-pathologic correlation. Radiographics. 1999;19(2):453–71.

    PubMed  CAS  Google Scholar 

  4. IchikawaT, Federle MP, Grazioli L, Madariaga J, Nalesnik M, Marsh W. Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology. 1999;213(2):352–61.

  5. Sarode VR, Castellani R, Post A. Fine-needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: case report. Diagn Cytopathol. 2002;26(2):95–8.

    Article  PubMed  Google Scholar 

  6. Nagorney DM, Adson MA, Weiland LH, Knight CD, Smalley SR, Zinsmeister AR. Fibrolamellar carcinoma. Am J Surg. 1985;149:113–9.

    Article  PubMed  CAS  Google Scholar 

  7. Stipa F, Yoon SS, Liau KH, Fong Y, Jarnagin WR, D’Angelica M, et al. Outcome of patients with fibrolamellar hepatocellular carcinoma. Cancer. 2006;106(6):1331–8.

    Article  PubMed  Google Scholar 

  8. Malouf GG, Brugières L, Le Deley MC, Faivre S, Fabre M, Paradis V, et al. Pure and mixed fibrolamellar hepatocellular carcinomas differ in natural history and prognosis after complete surgical resection. Cancer. 2012;118(20):4981–90. doi:10.1002/cncr.27520.Epub2012Mar13.

    Article  PubMed  Google Scholar 

  9. Liu S, Chan KW, Wang B, Qiao L. Fibrolamellar hepatocellular carcinoma. Am J Gastroenterol. 2009;104(10):2617–24.

    Article  PubMed  Google Scholar 

  10. Vecchio FM. Fibrolamellar carcinoma of the liver: a distinct entity within the hepatocellular tumors. A review. Appl Pathol. 1988;6(2):139–48.

    PubMed  CAS  Google Scholar 

  11. Vecchio FM, Fabiano A, Ghirlanda G, Manna R, Massi G. Fibrolamellar carcinoma of the liver: the malignant counterpart of focal nodular hyperplasia with oncocytic change. Am J Clin Pathol. 1984;81(4):521–6.

    PubMed  CAS  Google Scholar 

  12. Smith MT, Blatt ER, Jedlicka P, Strain JD, Fenton LZ. Best cases from the AFIP: fibrolamellar hepatocellular carcinoma. Radiographics. 2008;28:609–13.

    Article  PubMed  Google Scholar 

  13. Brandt DJ, Johnson CD, Stephens DH, Weilan LH. Imaging of fibrolamellar hepatocellular carcinoma. AJR Am J Roentgenol. 1988;151:295–9.

    Article  PubMed  CAS  Google Scholar 

  14. Friedman AC, Lichtenstein JE, Goodman ZD, Fishman EK, Siegelman SS, Dachman AH. Fibrolamellar hepatocellular carcinoma. Radiology. 1985;157:583–7.

    PubMed  CAS  Google Scholar 

  15. Corrigan K, Semelka RC. Dynamic contrast-enhanced MR imaging of fibrolamellar hepatocellular carcinoma. Abdom Imaging. 1995;20:122–5.

    Article  PubMed  CAS  Google Scholar 

  16. Titelbaum DS, Hatabu H, Schiebler ML, Kressel HY, Burke DR, Saul SH. Fibrolamellar hepatocellular carcinoma: MR appearance. J Comput Assist Tomogr. 1988;12:588–91.

    Article  PubMed  CAS  Google Scholar 

  17. Kim T, Hori M, Onishi H. Liver masses with central or eccentric scar. Semin Ultrasound CT MR. 2009;30(5):418–25.

    Article  PubMed  Google Scholar 

  18. Grazioli L, Morana G, Kirchin MA, Schneider G. Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology. 2005;236(1):166–77.

    Article  PubMed  Google Scholar 

  19. Soyer P, Roche A, Levesque M. Fibrolamellar hepatocellular carcinoma presenting with obstructive jaundice: a report of two cases. Eur J Radiol. 1991;13:196–8.

    Article  PubMed  CAS  Google Scholar 

  20. Gabata T, Terayama N, Kobayashi S, Sanada J, Kadoya M, Matsui O. MR imaging of hepatocellular carcinomas with biliary tumor thrombi. Abdom Imaging. 2007;32:470–4.

    Article  PubMed  Google Scholar 

  21. De Raffele E, Mirarchi M, Bassi F, Cola B. Hepatocellular carcinoma with neoplastic thrombosis of the common bile duct. Chir Ital. 2008;60:849–62.

    PubMed  Google Scholar 

  22. Masuda N, Shiraishi Y, Okubo K, Okada T, Segawa T, Takada M, et al. A case report of renal cell carcinoma with metastatic intraductal tumor thrombus of the common bile duct. Hinyokika Kiyo. 2009;55(2):99–102.

    PubMed  Google Scholar 

  23. Shito M, Kakefuda T, Omori T, Ishii S, Sugiura H. Primary non-Hodgkin’s lymphoma of the main hepatic duct junction. J Hepatobiliary Pancreat Surg. 2008;15(4):440–3.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Bio-Sciences and Radiological Imaging, Catholic University of the Sacred Heart, Rome, Italy

    Anna Maria De Gaetano, Rosellina Russo & Lorenzo Bonomo

  2. Department of Surgery, Transplantation Service, Catholic University of the Sacred Heart, Largo A. Gemelli, 8, 00168, Rome, Italy

    Erida Nure, Ugo Grossi, Francesco Frongillo, Maria Carmen Lirosi, Gabriele Sganga & Salvatore Agnes

  3. Department of Pathology, Catholic University of the Sacred Heart, Rome, Italy

    Fabio Maria Vecchio

  4. Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy

    Carla Felice

Authors
  1. Anna Maria De Gaetano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Erida Nure
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ugo Grossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Francesco Frongillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rosellina Russo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fabio Maria Vecchio
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maria Carmen Lirosi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Gabriele Sganga
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Carla Felice
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Lorenzo Bonomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Salvatore Agnes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ugo Grossi.

About this article

Cite this article

De Gaetano, A.M., Nure, E., Grossi, U. et al. Fibrolamellar hepatocellular carcinoma with biliary tumor thrombus: an unreported association. Jpn J Radiol 31, 706–712 (2013). https://doi.org/10.1007/s11604-013-0233-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-013-0233-5

Keywords

Search

Navigation