Selective intraarterial chemoradiation therapy for oropharyngeal carcinoma with high-dose cisplatin

  • Ryota Nishio
  • Kazuhiro Saito
  • Hiroyuki Ito
  • Tomoyuki Yoshida
  • Koichi Kitamura
  • Akira Shimizu
  • Naoto Kanesaka
  • Ryuji Mikami
  • Daisuke Hasegawa
  • Mamoru Suzuki
  • Koichi Tokuuye
Original Article

Abstract

Purpose

Cisplatin has shown a high tumor response rate among head and neck carcinomas, and the tumor response is related to the cisplatin dosage. The purpose of this study was to evaluate the efficacy and toxicity of selective intraarterial chemoradiation therapy for oropharyngeal carcinomas with high-dose cisplatin.

Materials and methods

This retrospective study consisted of 21 patients with oropharyngeal carcinoma, stages II-IVB, in whom intraarterial chemoradiation therapy was performed between 2000 and 2008. All patients were given two courses of selective intraarterial infusions of cisplatin (300 mg/m2), systemic chemotherapy with 5-fluorouracil, and simultaneous radiation therapy (58–61 Gy/30 fractions), with a 1-week rest period.

Results

The 2-year overall survival rate of the 15 patients who completed the therapeutic regimen was 71.3%. The 2-year locoregional control rate and disease-free survival rate were 95.0% and 67.7%, respectively.

Conclusion

Selective intraarterial high-dose cisplatin chemotherapy with concomitant radiation therapy shows results similar to those of original methods in terms of survival and locoregional control with a reduction in the number of procedure times.

Key words

Oropharyngeal carcinoma Intraarterial chemotherapy Cisplatin Interventional radiology 

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Copyright information

© Japan Radiological Society 2011

Authors and Affiliations

  • Ryota Nishio
    • 1
  • Kazuhiro Saito
    • 1
  • Hiroyuki Ito
    • 2
  • Tomoyuki Yoshida
    • 2
  • Koichi Kitamura
    • 2
  • Akira Shimizu
    • 2
  • Naoto Kanesaka
    • 1
  • Ryuji Mikami
    • 1
  • Daisuke Hasegawa
    • 1
  • Mamoru Suzuki
    • 2
  • Koichi Tokuuye
    • 1
  1. 1.Department of RadiologyTokyo Medical UniversityTokyoJapan
  2. 2.Department of OtolaryngologyTokyo Medical UniversityTokyoJapan

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