Japanese Journal of Radiology

, Volume 28, Issue 9, pp 663–671 | Cite as

Structural and neurochemical evaluation of the brain and pons in patients with Wilson’s disease

  • Oktay AlginEmail author
  • Ozlem Taskapilioglu
  • Bahattin Hakyemez
  • Gokhan Ocakoglu
  • Sukran Yurtogullari
  • Sevda Erer
  • Mufit Parlak
Original Article



The aim of this study was to examine the structural-neurochemical abnormalities of the frontal white matter (FWM), deep gray matter nuclei, and pons in patients with Wilson’s disease (WD) using proton magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI).

Materials and methods

Nine patients with WD and 14 age-matched controls were examined with MRS. N-Acetylaspartate (NAA), choline (Cho), and creatine (Cr) peaks were calculated. DWI scans from six WD patients and six controls were also obtained. The relative metabolite ratios and apparent diffusion coefficient (ADC) values of the WD patients were compared to those of the control subjects by using statistical measures.


Measurements in the thalamus and pons showed significantly lower NAA/Cho and NAA/Cr ratios in the WD group than in the control group (P < 0.05). Thalamic and pontine Cho/Cr ratios in the patient group were significantly higher than those of the control group (P < 0.05). No statistically significant relation was found between the patient and control groups as a result of the MRS examinations of FWM and all ADC measurements (P > 0.05).


MRS is a noninvasive, valuable modality for detecting structural-neurochemical changes of the brain stem and deep gray matter in patients with WD. The contribution of DWI in these patients is limited.

Key words

Wilson’s disease Proton MR spectroscopy Neuroimaging Diffusion magnetic resonance imaging Neuronal loss 


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Copyright information

© Japan Radiological Society 2010

Authors and Affiliations

  • Oktay Algin
    • 1
    • 2
    Email author
  • Ozlem Taskapilioglu
    • 3
  • Bahattin Hakyemez
    • 4
  • Gokhan Ocakoglu
    • 5
  • Sukran Yurtogullari
    • 3
  • Sevda Erer
    • 3
  • Mufit Parlak
    • 4
  1. 1.Department of RadiologyAtatürk Training and Research HospitalAnkaraTurkey
  2. 2.National Magnetic Resonance Research CenterAnkaraTurkey
  3. 3.Department of NeurologyUludag University Medical FacultyGorukle, BursaTurkey
  4. 4.Department of RadiologyUludag University Medical FacultyGorukle, BursaTurkey
  5. 5.Department of BiostatisticsUludag University Medical FacultyGorukle, BursaTurkey

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