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Japanese Journal of Radiology

, Volume 28, Issue 3, pp 199–204 | Cite as

Role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography for therapy evaluation of patients with large-vessel vasculitis

  • Francesco BertagnaEmail author
  • Giovanni Bosio
  • Federico Caobelli
  • Federica Motta
  • Giorgio Biasiotto
  • Raffaele Giubbini
Original Article

Abstract

Purpose

Systemic vasculitis is a multisystem disease characterized by inflammation of blood vessels. Diagnosing extension of the disease and evaluating the response to therapy are cornerstones in the clinical management of vasculitis, and imaging has a pivotal role in this field.

Materials and methods

We have evaluated nine patients with large-vessel vasculitis by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) before and after treatment with corticosteroid.

Results

The evaluation of eight patients was negative at follow-up studies after therapy, and one was unchanged.

Conclusions

18F-FDG-PET/CT is a useful, accurate tool for establishing the diagnosis of large-vessel vasculitis and for evaluating disease extension in these patients. Despite the small number of patients enrolled, our study confirms this statement and offers preliminary evidence that it could also be a reliable, accurate tool for monitoring therapy in conjunction with clinical and biochemical findings.

Key words

PET Vasculitis Therapy 

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Copyright information

© Japan Radiological Society 2010

Authors and Affiliations

  • Francesco Bertagna
    • 1
    Email author
  • Giovanni Bosio
    • 1
  • Federico Caobelli
    • 2
  • Federica Motta
    • 2
  • Giorgio Biasiotto
    • 3
  • Raffaele Giubbini
    • 2
  1. 1.Department of Nuclear MedicineSpedali Civili di BresciaBresciaItaly
  2. 2.Department of Nuclear MedicineUniversity of BresciaBresciaItaly
  3. 3.Dipartimento Materno Infantile e Tecnologie BiomedicheUniversity of BresciaBresciaItaly

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