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Japanese Journal of Radiology

, Volume 28, Issue 3, pp 220–223 | Cite as

Palliative radiotherapy with 1 × 8 Gy using conformal radiotherapy for chemotherapy-refractory, recurrent, aggressive lymphomas

  • Munetaka MatobaEmail author
  • Kiyotaka Oota
  • Hisao Tonami
  • Yasufumi Masaki
  • Tomouki Sakai
  • Hisanori Umehara
Case Report

Abstract

We performed palliative radiotherapy with a single-fraction of 8 Gy using a three-dimensional conformal radiotherapy (3D-CRT) technique for patients with dyspnea due to a bulky nasooropharyngeal lesion who had chemotherapy-refractory, recurrent, aggressive lymphoma. After palliative radiotherapy, a complete response with acceptable toxicity was achieved at the irradiated sites of two patients, and the symptoms resolved completely. These results indicated that a single fraction of 8 Gy using 3D-CRT is an effective palliative treatment for chemotherapy-refractory, recurrent, aggressive lymphoma.

Key words

Lymphoma Radiotherapy Palliation Hypofraction 

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References

  1. 1.
    Haas RL, Poortmans P, de Jong D, Aleman BM, Dewit LG, Verheij M, et al. High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas. J Clin Oncol 2003;21:2474–2480.CrossRefPubMedGoogle Scholar
  2. 2.
    Haas RL, Poortmans P, de Jong D, Verheij M, van der Hulst M, de Boer JP, et al. Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients. Eur J Cancer 2005;41:1724–1730.CrossRefPubMedGoogle Scholar
  3. 3.
    Murthy V, Thomas K, Foo K, Cunningham, D, Johnson B, Norman A, et al. Efficacy of palliative low-dose involved field radiation therapy in advanced lymphoma: a phase II study. Clin Lymphoma Myeloma 2008;8:241–245.CrossRefPubMedGoogle Scholar
  4. 4.
    Porceddu SV, Rosser B, Burmeister BH, Jones M, Hickey B, Baumann K, et al. Hypofractionated radiotherapy for the palliation of advanced head and neck cancer in patients unsuitable for curative treatment-“Hypo Trial.” Radiother Oncol 2007;85:456–462.CrossRefPubMedGoogle Scholar
  5. 5.
    Lutz ST, Chow EL, Hartsell WF, Konski AA. A review of hypofractionated palliative radiotherapy. Cancer 2007;109:1462–1470.CrossRefPubMedGoogle Scholar
  6. 6.
    Tanaka O, Oguchi M, Nose T, Kozuka T, Kumada M, Nemoto K, et al. Abstract presented at the JASTRO scientific meeting, 2007;suppl 19:208.Google Scholar
  7. 7.
    Miller TP, Dahlberg S, Cassady JR, Adelstein DJ, Spier CM, Grogan TM, et al. Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin’s lymphoma. N Engl J Med 1998;339:21–26.CrossRefPubMedGoogle Scholar
  8. 8.
    Leitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM. Limited-stage mantle-cell lymphoma. Ann Oncol 2003;14:1555–1561.CrossRefPubMedGoogle Scholar
  9. 9.
    Haddad P, Wong RK, Pond GR, Soban F, Williams D, McLean M, et al. Factors influencing the use of single vs multiple fractions of palliative radiotherapy for bone metastases: a 5-year review. Clin Oncol 2005;17:430–434.CrossRefGoogle Scholar
  10. 10.
    Wu JS, Wong R, Johnston M, Bezjak A, Whelan T. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 2003;55:594–605.PubMedGoogle Scholar

Copyright information

© Japan Radiological Society 2010

Authors and Affiliations

  • Munetaka Matoba
    • 1
    Email author
  • Kiyotaka Oota
    • 1
  • Hisao Tonami
    • 1
  • Yasufumi Masaki
    • 2
  • Tomouki Sakai
    • 2
  • Hisanori Umehara
    • 2
  1. 1.Department of RadiologyKanazawa Medical UniversityIshikawaJapan
  2. 2.Department of Internal MedicineKanazawa Medical UniversityIshikawaJapan

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