Japanese Journal of Radiology

, Volume 28, Issue 1, pp 15–19 | Cite as

Kikuchi disease: 18F-FDG positron emission tomography/computed tomography of lymph node uptake

Original Article



This study evaluated 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings in patients with Kikuchi disease (KD), or histiocytic necrotizing lymphadenitis.

Materials and methods

We evaluated the 18F-FDG PET/ CT findings of seven patients (one man, six women) with KD, ranging in age from 23 to 66 years (mean 36 years). All the patients had been diagnosed based on the pathological findings of a biopsy and clinical course.


The maximum standard uptake values (SUVmax) of FDG uptake in affected lymph nodes were 2.05–13.94 (mean ± SD, 6.25 ± 3.32). In all the patients but two, the lymph nodes with the SUVmax were located in the neck. All the lymph nodes had a diameter of <30 mm. In nonneck regions, the SUVs of the swollen lymph nodes tended to indicate lower uptake.


FDG-PET/CT was capable of visualizing general regions containing lymph nodes and was useful for making clinical decisions as to biopsy sites. Together with the physical findings, consideration of the distribution and size of the affected lymph nodes, as shown using FDG-PET/CT, may be useful for suggesting the possibility of KD. KD should be considered in the differential diagnosis of FDG-avid lymph node lesions.

Key words

Kikuchi disease PET/CT 18F-FDG Necrotizing histiocytic lymphadenitis 


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  1. 1.
    Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol 2004;122:141–152.CrossRefPubMedGoogle Scholar
  2. 2.
    Kim CH, Hyun OJ, Yoo IeR, Kim SH, Sohn HS, Chung SK. Kikuchi disease mimicking malignant lymphoma on FDG PET/CT. Clin Nucl Med 2007;32:711–712.CrossRefPubMedGoogle Scholar
  3. 3.
    Chamulak GA, Brynes RK, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol 1990;14:514–523.PubMedCrossRefGoogle Scholar
  4. 4.
    Mootsikapun P, Sirijerachai J, Nanagara R. Kikuchi-Fujimoto’s disease, histiocytic necrotizing lymphadenitis, mimicking systemic lupus erythematosus. J Med Assoc Thai 2002;85:1037–1041.PubMedGoogle Scholar
  5. 5.
    Jayaraj SM, Lloyd J, Frosh AC, Patel KS. Kikuchi-Fujimoto’s syndrome masquerading as tuberculosis. J Laryngol Otol 1999;113:82–84.PubMedGoogle Scholar
  6. 6.
    Kwon SY, Kim TK, Kim YS, Lee KY, Lee NJ, Seol HY. CT findings in Kikuchi disease: analysis of 96 cases. AJNR Am J Neuroradiol 2004;25:1099–1102.PubMedGoogle Scholar
  7. 7.
    Na DG, Chung TS, Byun HS, Kim HD, Ko YH, Yoon JH. Kikuchi disease: CT and MRI findings. AJNR Am J Neuroradiol 1997;18:1729–1732.PubMedGoogle Scholar
  8. 8.
    Miller WT Jr, Perez-Jaffe LA. Cross-sectional imaging of Kikuchi disease. J Comput Assist Tomogr 1999;23:548–551.CrossRefPubMedGoogle Scholar
  9. 9.
    Kaicker S, Gerard PS, Kalburgi S, Geller MD, Hailoo D. PET-CT scan in a patient with Kikuchi disease. Pedatr Radiol 2008;38:596–597.CrossRefGoogle Scholar
  10. 10.
    Liao AC, Chen YK. Cervical lymphadenopathy caused by Kikuchi disease: positron emission tomographic appearance. Clin Nucl Med 2003;28:320–321.CrossRefPubMedGoogle Scholar
  11. 11.
    Hudnall SD, Chen T, Amr S, Young KH, Henry K. Detection of human herpesvirus DNA in Kikuchi-Fujimoto disease and reactive lymphoid hyperplasia. Int J Clin Exp Pathol 2008;1:362–368.PubMedGoogle Scholar
  12. 12.
    Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 1988;5:329–345.PubMedGoogle Scholar

Copyright information

© Japan Radiological Society 2010

Authors and Affiliations

  1. 1.Department of Nuclear MedicineSaitama Medical University International Medical CenterHidakaJapan
  2. 2.Department of Nuclear MedicineInternational Medical Center of JapanTokyoJapan

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