Japanese Journal of Radiology

, Volume 27, Issue 1, pp 4–19 | Cite as

Spectrum of Epstein-Barr virus-related diseases: a pictorial review

  • Eriko MaedaEmail author
  • Masaaki Akahane
  • Shigeru Kiryu
  • Nobuyuki Kato
  • Takeharu Yoshikawa
  • Naoto Hayashi
  • Shigeki Aoki
  • Manabu Minami
  • Hiroshi Uozaki
  • Masashi Fukayama
  • Kuni Ohtomo


Epstein-Barr virus (EBV) prevails among more than 90% of the adult population worldwide. Most primary infections occur during young childhood and cause no or only nonspecific symptoms; then the virus becomes latent and resides in lymphocytes in the peripheral blood. Inactive latent EBV usually causes no serious consequences, but once it becomes active it can cause a wide spectrum of malignancies: epithelial tumors such as nasopharyngeal and gastric carcinomas; mesenchymal tumors such as follicular dendritic cell tumor/sarcoma; and lymphoid malignancies such as Burkitt lymphoma, lymphomatoid granulomatosis, pyothorax-associated lymphoma, immunodeficiency-associated lymphoproliferative disorders, extranodal natural killer (NK) cell/T-cell lymphoma, and Hodgkin’s lymphoma. The purpose of this article is to describe the spectrum of EBV-related diseases and their key imaging findings. EBV-related lymphoproliferative disorders and lymphomas are especially common in immunocompromised patients. Awareness of their clinical settings and imaging spectrum contributes to early detection and early treatment of possibly life-threatening disorders.

Key words

Epstein-Barr virus EBV-associated gastric carcinoma Follicular dendritic cell tumor Lymphoma Lymphoproliferative disorder Immunodeficiency 


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Copyright information

© Japan Radiological Society 2009

Authors and Affiliations

  • Eriko Maeda
    • 1
    Email author
  • Masaaki Akahane
    • 1
  • Shigeru Kiryu
    • 2
  • Nobuyuki Kato
    • 1
  • Takeharu Yoshikawa
    • 1
  • Naoto Hayashi
    • 1
  • Shigeki Aoki
    • 1
  • Manabu Minami
    • 3
  • Hiroshi Uozaki
    • 4
  • Masashi Fukayama
    • 4
  • Kuni Ohtomo
    • 1
  1. 1.Department of Radiology, Graduate School of MedicineThe University of TokyoTokyoJapan
  2. 2.Department of Radiology, Institute of Medical ScienceThe University of TokyoTokyoJapan
  3. 3.Department of RadiologyTsukuba University HospitalTsukubaJapan
  4. 4.Department of Pathology, Graduate School of MedicineThe University of TokyoTokyoJapan

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