Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer
- 437 Downloads
The purpose of this study was to examine the relation between cancer cellularity and the apparent diffusion coefficient (ADC) value using diffusion-weighted magnetic resonance imaging in breast cancer.
Materials and methods
The subjects were 27 women who had undergone operation for breast cancer. There were 27 breast cancer lesions, 24 of which were invasive ductal carcinoma (IDC) and 3 of which were noninvasive ductal carcinoma (NIDC).
The mean ADC values of IDC, NIDC, and normal breasts were 1.07 ± 0.19 ·10−3, 1.42 ± 0.17 ·10−3, and 1.96 ± 0.21 ·10−3 mm2/s, respectively. The mean ADC values of IDC and NIDC were signifi cantly different from that of normal breasts (P < 0.001 each). The mean ADC values were also signifi cantly different between IDC and NIDC (P < 0.001). There was no correlation between the ADC value and cancer cellularity.
The mean ADC values for breast cancer were significantly different from that of normal breasts. The mean ADC value for breast cancer did not significantly correlate with cancer cellularity but did correlate with histological types.
Key wordsBreast cancer MRI Diffusion-weighted imaging Cellularity Apparent diffusion coefficient value
Unable to display preview. Download preview PDF.
- 1.Lebihan D, Turner R, Douek P, Patronas N. Diffusion MR imaging: clinical applications. AJR Am J Roentgenol 1992;159:591–599.Google Scholar
- 15.Woodhams R, Matsunaga K, Iwabuchi K, Kan S, Hata H, Kuranami M, et al. Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coeffi cient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension. J Comput Assist Tomogr 2005;29:644–649.PubMedCrossRefGoogle Scholar