Radiation Medicine

, Volume 26, Issue 4, pp 222–226 | Cite as

Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer

  • Miho I. YoshikawaEmail author
  • Shozo Ohsumi
  • Shigenori Sugata
  • Masaaki Kataoka
  • Shigemitsu Takashima
  • Teruhito Mochizuki
  • Hirohiko Ikura
  • Yutaka Imai
Original Article



The purpose of this study was to examine the relation between cancer cellularity and the apparent diffusion coefficient (ADC) value using diffusion-weighted magnetic resonance imaging in breast cancer.

Materials and methods

The subjects were 27 women who had undergone operation for breast cancer. There were 27 breast cancer lesions, 24 of which were invasive ductal carcinoma (IDC) and 3 of which were noninvasive ductal carcinoma (NIDC).


The mean ADC values of IDC, NIDC, and normal breasts were 1.07 ± 0.19 ·10−3, 1.42 ± 0.17 ·10−3, and 1.96 ± 0.21 ·10−3 mm2/s, respectively. The mean ADC values of IDC and NIDC were signifi cantly different from that of normal breasts (P < 0.001 each). The mean ADC values were also signifi cantly different between IDC and NIDC (P < 0.001). There was no correlation between the ADC value and cancer cellularity.


The mean ADC values for breast cancer were significantly different from that of normal breasts. The mean ADC value for breast cancer did not significantly correlate with cancer cellularity but did correlate with histological types.

Key words

Breast cancer MRI Diffusion-weighted imaging Cellularity Apparent diffusion coefficient value 


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Copyright information

© Japan Radiological Society 2008

Authors and Affiliations

  • Miho I. Yoshikawa
    • 1
    Email author
  • Shozo Ohsumi
    • 2
  • Shigenori Sugata
    • 3
  • Masaaki Kataoka
    • 3
  • Shigemitsu Takashima
    • 2
  • Teruhito Mochizuki
    • 4
  • Hirohiko Ikura
    • 1
  • Yutaka Imai
    • 5
  1. 1.Department of Radiology, Tokai University School of MedicineTokai University Hachioji HospitalTokyoJapan
  2. 2.Department of Breast SurgeryNational Hospital Organization Shikoku Cancer CenterMatsuyamaJapan
  3. 3.Department of RadiologyNational Hospital Organization Shikoku Cancer CenterMatsuyamaJapan
  4. 4.Department of Diagnostic and Therapeutic RadiologyEhime University Graduate School of MedicineToonJapan
  5. 5.Department of RadiologyTokai University School of MedicineIseharaJapan

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