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Intracranial carotid calcification on CT images as an indicator of atheromatous plaque: analysis of high-resolution CTA images using a 64-multidetector scanner

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Abstract

Purpose

Intracranial arterial wall calcifications are frequently observed on routine head computed tomography (CT) images. The purpose of this study was to evaluate whether calcification of the intracranial carotid artery on CT images could predict atheromatous plaque and luminal stenosis.

Materials and methods

A total of 259 patients were examined using three-dimensional CT angiography using high-resolution 64 detector scanners. We examined patients from the petrous portion to the top of the internal carotid arteries. We evaluated the existence of calcification and atheromatous plaque based on our criteria retrospectively. The thickness of calcification was measured in each vessel, and the shape of calcification was classified into three types.

Results

There was low correlation between the thickness of the calcification and luminal stenosis, but the shape of the calcification corresponded well to the stenosis. The population of patients with >50% stenosis of the intracranial carotid artery differed statistically significantly for each calcification shape. There was a high negative predictive value (97.7%) in the correlation between the existence of calcification and atheromatous plaque on the multidetector CT images.

Conclusion

Calcification of the intracranial carotid artery on CT images shows a high negative predictive value for the existence of atheromatous plaque in the same artery. The thickness of the calcification did not correlate well with luminal stenosis, but its shape seemed to predict luminal stenosis.

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References

  1. RJ Woodcock JH Goldstein DF Kallmes HJ Cloft CD Phillips (1999) ArticleTitleAngiographic correlation of CT calcification in the carotid siphon Am J Neuroradiol 20 495–9 Occurrence Handle10219418

    PubMed  Google Scholar 

  2. T Taoka S Iwasaki H Nakagawa M Sakamoto A Fukusumi K Takayama et al. (2006) ArticleTitleEvaluation of arteriosclerotic changes in the intracranial carotid artery using the calcium score obtained on plain cranial computed tomography scan: correlation with angiographic changes and clinical outcome J Comput Assist Tomogr 30 624–8 Occurrence Handle16845294 Occurrence Handle10.1097/00004728-200607000-00012

    Article  PubMed  Google Scholar 

  3. YH Sohn HY Cheon P Jeon SY Kang (2004) ArticleTitleClinical implication of cerebral artery calcification on brain CT Cerebrovasc Dis 18 332–7 Occurrence Handle15359101 Occurrence Handle10.1159/000080772

    Article  PubMed  Google Scholar 

  4. LS Babiarz DM Yousem BA Wasserman C Wu W Bilker NJ Beauchamp SuffixJr (2003) ArticleTitleCavernous carotid artery calcification and white matter ischemia AJNR Am J Neuroradiol 24 872–7 Occurrence Handle12748087

    PubMed  Google Scholar 

  5. LS Babiarz DM Yousem W Bilker BA Wasserman (2005) ArticleTitleMiddle cerebral artery infarction: relationship of cavernous carotid artery calcification AJNR Am J Neuroradiol 26 1505–11 Occurrence Handle15956522

    PubMed  Google Scholar 

  6. S Schroeder A Kuettner M Leitritz J Janzen AF Kopp C Herdeg et al. (2004) ArticleTitleReliability of differentiating human coronary plaque morphology using contrast-enhanced multislice spiral computed tomography: a comparison with histology J Comput Assist Tomogr 28 449–54 Occurrence Handle15232374 Occurrence Handle10.1097/00004728-200407000-00003

    Article  PubMed  Google Scholar 

  7. S Schroeder AF Kopp A Baumbach C Meisner A Kuettner C Georg et al. (2001) ArticleTitleNoninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography J Am Coll Cardiol 37 1430–5 Occurrence Handle11300457 Occurrence Handle10.1016/S0735-1097(01)01115-9 Occurrence Handle1:STN:280:DC%2BD3M3gvFKiuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  8. CR Becker K Nikolaou M Muders G Babaryka A Crispin UJ Schoepf et al. (2003) ArticleTitleEx vivo coronary atherosclerotic plaque characterization with multi-detector-row CT Eur Radiol 13 2094–8 Occurrence Handle12692681 Occurrence Handle10.1007/s00330-003-1889-5

    Article  PubMed  Google Scholar 

  9. PM Van Ooijen KY Ho J Dorgelo M Oudkerk (2003) ArticleTitleCoronary artery imaging with multidetector CT: visualization issues Radiographics 23 e16 Occurrence Handle12907810 Occurrence Handle10.1148/rg.e16

    Article  PubMed  Google Scholar 

  10. GH Glover NJ Pelc (1980) ArticleTitleNonlinear partial volume artifacts in X-ray computed tomography Med Phys 7 238–48 Occurrence Handle7393149 Occurrence Handle10.1118/1.594678 Occurrence Handle1:STN:280:Bi%2BB3s3isVc%3D

    Article  PubMed  CAS  Google Scholar 

  11. Y Liu KD Hopper DT Mauger KA Addis (2000) ArticleTitleCT angiographic measurement of the carotid artery: optimizing visualization by manipulating window and level settings and contrast material attenuation Radiology 217 494–500 Occurrence Handle11058651 Occurrence Handle1:STN:280:DC%2BD3crhtFCisg%3D%3D

    PubMed  CAS  Google Scholar 

  12. MI Chimowitz J Kokkinos J Strong MB Brown SR Levine S Silliman et al. (1995) ArticleTitleThe warfarin-asprin symptomatic intracranial disease study Neurology 45 1488–93 Occurrence Handle7644046 Occurrence Handle1:STN:280:ByqA2s7ovVM%3D

    PubMed  CAS  Google Scholar 

  13. T Ptak GH Hunter R Avakian RA Novelline (2003) ArticleTitleClinical significance of cavernous carotid calcifications encountered on head computed tomography scans performed on patients seen in the emergency department J Comput Assist Tomogr 27 505–9 Occurrence Handle12886133 Occurrence Handle10.1097/00004728-200307000-00009

    Article  PubMed  Google Scholar 

  14. DR Craig K Meguro C Watridge JT Robertson HJ Barnett AJ Fox (1982) ArticleTitleIntracranial internal carotid artery stenosis Stroke 13 825–8 Occurrence Handle7147298 Occurrence Handle1:STN:280:BiyD28fksVQ%3D

    PubMed  CAS  Google Scholar 

  15. DJ Marzewski AJ Furlan P St. Louis JR Little MT Modic G Williams (1982) ArticleTitleIntracranial internal carotid artery stenosis: long term prognosis Stroke 13 821–4 Occurrence Handle7147297 Occurrence Handle1:STN:280:BiyD28fktl0%3D

    PubMed  CAS  Google Scholar 

  16. S Leschka H Alkadhi A Plass L Desbiolles J Grunenfelder B Marincek et al. (2005) ArticleTitleAccuracy of MSCT coronary angiography with 64-slice technology: first experience Eur Heart J 26 1482–7 Occurrence Handle15840624 Occurrence Handle10.1093/eurheartj/ehi261

    Article  PubMed  Google Scholar 

  17. AW Leber A Becker A Knez F von Ziegler M Sirol K Nikolaou et al. (2006) ArticleTitleAccuracy of 64-slice computed tomography to classify and quantify plaque volumes in the proximal coronary system: a comparative study using intravascular ultrasound J Am Coll Cardiol 47 672–7 Occurrence Handle16458154 Occurrence Handle10.1016/j.jacc.2005.10.058

    Article  PubMed  Google Scholar 

  18. T Hirai Y Korogi K Ono Y Murata M Takahashi K Suginohara et al. (2001) ArticleTitleMaximum stenosis of extracranial internal carotid artery: effect of luminal morphology on stenosis measurement by using CT angiography and conventional DSA Radiology 221 802–9 Occurrence Handle11719682 Occurrence Handle10.1148/radiol.2213001746 Occurrence Handle1:STN:280:DC%2BD3Mnntlyjuw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  19. H Ota K Takase H Rikimaru M Tsuboi T Yamada A Sato et al. (2005) ArticleTitleQuantitative vascular measurements in arterial occlusive disease Radiographics 25 1141–58 Occurrence Handle16160101 Occurrence Handle10.1148/rg.255055014

    Article  PubMed  Google Scholar 

  20. GM Hass RE Trueheart A Hemmens (1961) ArticleTitleExperimental athero-arteriosclerosis due to calcific medial degeneration and hypercholesteremia Am J Pathol 38 289–96 Occurrence Handle13712152 Occurrence Handle1:CAS:528:DyaF38Xmtleqsg%3D%3D

    PubMed  CAS  Google Scholar 

  21. S Bash JP Villablanca R Jahan G Duckwiler M Tillis C Kidwell et al. (2005) ArticleTitleIntracranial vascular stenosis and occlusive disease: evaluation with CT angiography, MR angiography, and digital subtraction angiography AJNR Am J Neuroradiol 26 1012–21 Occurrence Handle15891154

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Michimasa Suzuki, Yutaka Ozaki, Shinji Komura & Atsushi Nakanishi

Authors
  1. Michimasa Suzuki
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  2. Yutaka Ozaki
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  3. Shinji Komura
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  4. Atsushi Nakanishi
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Corresponding author

Correspondence to Michimasa Suzuki.

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Suzuki, M., Ozaki, Y., Komura, S. et al. Intracranial carotid calcification on CT images as an indicator of atheromatous plaque: analysis of high-resolution CTA images using a 64-multidetector scanner. Radiat Med 25, 378–385 (2007). https://doi.org/10.1007/s11604-007-0153-3

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  • DOI: https://doi.org/10.1007/s11604-007-0153-3

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