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Current Medical Science

, Volume 39, Issue 2, pp 337–342 | Cite as

Absorption Characteristics of Novel Compound Calcium Carbonate Granules: Effects of Gastric Acid Deficiency and Exogenous Weak Acids

  • Hong-dan Chen
  • Yi-ping Chen
  • Rui Xie
  • Qin-yu Hu
  • Qi Cheng
  • Ming XiangEmail author
Article
  • 25 Downloads

Summary

Calcium carbonates are commonly administered as supplements for conditions of calcium deficiency. We report here pharmacokinetic characteristics of a novel formulation, calcium carbonate compound granules (CCCGs), forming complexes of calcium carbonate and calcium citrate in water. CCCGs were compared to a kind of commonly-used calcium carbonate D3 preparation (CC) in the market in 5-week-old mice that had been treated with omeprazole, to suppress gastric acid secretion, and in untreated control mice. The results showed that: (1) CCCGs had better water solubility than CC in vitro; (2) In control mice, calcium absorption rates after CCCGs administration were comparable to those after CC administration; (3) Inhibition of gastric acid secretion did not affect calcium absorption after CCCGs, but moderately decreased it after CC; (4) The presence of phytic acid or tannin did not affect calcium absorption rates after CCCGs but did for CC; and (5) In normal mice, CCCGs did not inhibit gastric emptying and intestinal propulsion, and did not alter the gastrointestinal hormones. The results suggest that CCCGs may be therapeutically advantageous over more commonly used calcium supplement formulations, particularly for adolescents, because of their stable calcium absorption characteristics and their relatively favorable adverse effect profile.

Key words

calcium carbonate gastric acid inhibition phytic acid tannin calcium absorption 

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Notes

Acknowledgments

We gratefully acknowledged Prof. Robert L. Rodgers, Biomedical Department, Pharmaceutical Sciences, University of Rhode Island, USA for providing constructive discussions and language editing.

References

  1. 1.
    Heaney RP, Kopecky S, Maki KC, et al. A review of calcium supplements and cardiovascular disease risk. Adv Nutr, 2012,3(6):763–771CrossRefGoogle Scholar
  2. 2.
    Tamamura Y, Yamaguchi A. Bone and tooth in calcium and phosphate metabolism. Clin Calcium (Japanese), 2012,22(1):11–17Google Scholar
  3. 3.
    Nakashima T. Bone and Calcium Metabolisms Associated with Dental and Oral-Maxillofacial Diseases. Bone remodeling and alveolar bone homeostasis. Clin Calcium (Japanese), 2015,25(8):1220–1228Google Scholar
  4. 4.
    Hawkins TE, Merrifield CJ, Moss SE, et al. Calcium signaling and annexins. Cell Biochem Biophys, 2000,33(3):275–296CrossRefGoogle Scholar
  5. 5.
    Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab, 2011,96(1):53–58CrossRefGoogle Scholar
  6. 6.
    NIH Consensus conference. Optimal calcium intake. NIH Consensus Development Panel on Optimal Calcium Intake. JAMA, 1994,272(24):1942–1948CrossRefGoogle Scholar
  7. 7.
    Balk EM, Adam GP, Langberg VN, et al. Global dietary calcium intake among adults: a systematic review. Osteoporos Int, 2017,28(12):3315–3324CrossRefGoogle Scholar
  8. 8.
    Abrams SA. Calcium absorption in infants and small children: methods of determination and recent findings. Nutrients, 2010,2(4):474–480CrossRefGoogle Scholar
  9. 9.
    Sobczak M, Jablonski E. Mineral elements in diet of pregnant and breast-feeding women. Part I. Macro minerals: calcium, magnesium, phosphorus, sodium, potassium, chloride. Przegl Lek, 2007,64(3):165–169Google Scholar
  10. 10.
    Hawkins TE, Merrifield CJ, Moss SE. Calcium and vitamin D supplements improve cholesterol in older women. Harv Womens Health Watchm, 2014,21(10):8Google Scholar
  11. 11.
    Manson JE, Bassuk SS. Calcium supplements: do they help or harm? Menopause, 2014,21(1):106–108CrossRefGoogle Scholar
  12. 12.
    Bauer DC. Clinical practice. Calcium supplements and fracture prevention. N Engl J Med, 2013,369(16):1537–1543CrossRefGoogle Scholar
  13. 13.
    Huang J, Ou HY, Chiu KC, et al. Calcium supplements and fracture prevention. N Engl J Med, 2014,370(4):387Google Scholar
  14. 14.
    Hsia J, Heiss G, Ren H, et al. Calcium/vitamin D supplementation and cardiovascular events. Circulation, 2007,115(7):846–854CrossRefGoogle Scholar
  15. 15.
    Ye L, Morse LR, Zhang L, et al. Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption. PLoS Genet, 2015,11(3):e1005057CrossRefGoogle Scholar
  16. 16.
    Kopic S, Geibel JP. Gastric acid, calcium absorption, and their impact on bone health. Physiol Rev, 2013,93(1):189–268CrossRefGoogle Scholar
  17. 17.
    Keller J, Schinke T. The role of the gastrointestinal tract in calcium homeostasis and bone remodeling. Osteoporos Int, 2013,24(11):2737–2748CrossRefGoogle Scholar
  18. 18.
    Hiligsmann M, Ben Sedrine W, Bruyere O, et al. Cost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis. Eur J Public Health, 2015,25(1):20–25CrossRefGoogle Scholar
  19. 19.
    Aloia JF, Dhaliwal R, Shieh A, et al. Calcium and vitamin D supplementation in postmenopausal women. J Clin Endocrinol Metab, 2013,98(11):E1702–1709CrossRefGoogle Scholar
  20. 20.
    Hanzlik RP, Fowler SC, Fisher DH. Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate. J Pharmacol Exp Ther, 2005,313(3):1217–1222CrossRefGoogle Scholar
  21. 21.
    Satoh K, Kase Y, Yuzurihara M, et al. Effect of Daikenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice. J Ethnopharmacol, 2003,86(1):37–44CrossRefGoogle Scholar
  22. 22.
    Su SF, Yang AM, Yang SB, et al. Intracerebroventricular administration of neuronostatin delays gastric emptying and gastrointestinal transit in mice. Peptides, 2012,35(1):31–35CrossRefGoogle Scholar
  23. 23.
    Gompertz RH, Man WK, Li SK, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions, 1991,33(1–2):161–163CrossRefGoogle Scholar
  24. 24.
    Al-Mamary M, Molham AH, Abdulwali AA, et al. In vivo effects of dietary sorghum tannins on rabbit digestive enzymes and mineral absorption. Nutr Res, 2001,21(10):1393–1401CrossRefGoogle Scholar
  25. 25.
    Fausett H, Gayser C Jr, Dash AK, et al. Evaluation of quick disintegrating calcium carbonate tablets. AAPS Pharm Sci Tech, 2000,1(3):E20CrossRefGoogle Scholar
  26. 26.
    Johnson RN. A study of five calcium supplements: estimation of calcium absorption and sodium content. Eur J Clin Nutr, 1991,45(2):117–119Google Scholar
  27. 27.
    Reid IR, Mason B, Horne A, et al. Randomized controlled trial of calcium in healthy older women. Am J Med, 2006,119(9):777–785CrossRefGoogle Scholar
  28. 28.
    Salovaara K, Tuppurainen M, Karkkainen M, et al. Effect of vitamin D(3) and calcium on fracture risk in 65- to 71-year-old women: a population-based 3-year randomized, controlled trial—the OSTPRE-FPS. J Bone Miner Res, 2010,25(7):1487–1495CrossRefGoogle Scholar
  29. 29.
    Reid IR, Bristow SM, Bolland MJ. Calcium supplements: benefits and risks. J Intern Med, 2015,278(4):354–368CrossRefGoogle Scholar
  30. 30.
    Schwingshackl L, Hoffmann G, Buijsse B, et al. Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a protocol for a systematic review and network meta-analysis of primary prevention trials. Syst Rev, 2015,4:34CrossRefGoogle Scholar

Copyright information

© Huazhong University of Science and Technology 2019

Authors and Affiliations

  • Hong-dan Chen
    • 1
  • Yi-ping Chen
    • 2
  • Rui Xie
    • 1
  • Qin-yu Hu
    • 1
  • Qi Cheng
    • 1
  • Ming Xiang
    • 1
    Email author
  1. 1.Department of Pharmacology, School of Pharmacy, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Pediatric Infectious Diseases, Second Affiliated Hospital & Yuying Children’s HospitalWenzhou Medical UniversityWenzhouChina

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