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Current Medical Science

, Volume 39, Issue 2, pp 211–216 | Cite as

Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy

  • Na Shen
  • Yong You
  • Zhao-dong Zhong
  • Li Meng
  • Jian-feng Zhou
  • Ping Zou
  • Xiao-jian Zhu
  • Hong-xiang WangEmail author
  • Fan-jun ChengEmail author
Article
  • 51 Downloads

Summary

Discontinuation of tyrosine kinase inhibitor (TKI) therapy after achieving a persistent deep molecular response (DMR) is an urgently needed treatment goal for chronic myeloid leukemia (CML) patients and has been included in the National Comprehensive Cancer Network (NCCN) guidelines (version 2.2017) for CML. Indeed, various studies have confirmed the feasibility of discontinuing TKI therapy. In this study, we analyzed data from 45 CML patients who had discontinued TKI therapy. Univariate analysis was performed to predict factors that were potentially related to treatment-free remission (TFR) and identify the differences between early relapse and late relapse. Out of the 45 patients, 20 exhibited molecular relapse after a median follow-up of 18 months (range, 1–54 months), and the estimated TFR at 24 months was 40%. The univariate analysis revealed that a high Sokal score and interruptions or dose reductions during TKI treatment were the only baseline factors associated with poor outcomes. Our results indicate that TKI discontinuation could be successfully put into practice in China.

Key words

discontinuation treatment-free remission chronic myeloid leukemia relapse 

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Copyright information

© Huazhong University of Science and Technology 2019

Authors and Affiliations

  • Na Shen
    • 1
  • Yong You
    • 1
  • Zhao-dong Zhong
    • 1
  • Li Meng
    • 2
  • Jian-feng Zhou
    • 2
  • Ping Zou
    • 1
  • Xiao-jian Zhu
    • 2
  • Hong-xiang Wang
    • 3
    Email author
  • Fan-jun Cheng
    • 1
    Email author
  1. 1.Institute of Hematology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Hematology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  3. 3.Department of HematologyThe Central Hospital of WuhanWuhanChina

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