Current Medical Science

, Volume 39, Issue 1, pp 111–117 | Cite as

Apolipoprotein E Gene Polymorphisms Are Risk Factors for Spontaneous Intracerebral Hemorrhage: A Systematic Review and Meta-analysis

  • Hao Nie
  • Yang Hu
  • Na Liu
  • Ping Zhang
  • Gai-gai Li
  • Yan-yan Li
  • Chao Pan
  • Hai-han Yu
  • Qian Wu
  • Guo-feng WuEmail author
  • Zhou-ping TangEmail author


Intracerebral hemorrhage (ICH) is a serious clinical disease with high morbidity, whose pathogenesis might be related to apolipoprotein E (APOE) gene polymorphisms. To comprehensively evaluate the risk factors for ICH occurrence, we performed a meta-analysis. We searched online databases to identify eligible studies based on the relationship between APOE genetic polymorphisms and ICH occurrence risk. Specific and pooled odds ratios (ORs) were calculated and by assessing small study bias, we drew the relationship between APOE polymorphisms and ICH risk. We included 15 eligible studies in our study containing a total of 1642 ICH samples and 5545 normal controls. The comparison of ɛ4 and ɛ3 APOE genotypes revealed that specific and pooled ORs showed a significantly increased odds ratio in ICH patients with the ɛ4 genotype, indicating that ɛ4 gene is a risk factor for ICH occurrence, and the heterogeneity is acceptable. Similarly, it was found that the ɛ2 genotype also contributed to the incidence rate of ICH. However, after the subgroup analysis by ethnicity, this APOE genetic polymorphism acted as a harmful factor only in white populations, but did not show an effect in Asian populations. It was suggested that both ε2 and ε4 APOE alleles were risk factors for ICH in general. They were risk factors in white populations only, neither had a detectable effect in Asian populations after subgroup analysing by ethnicity.

Key words

intracerebral hemorrhage apolipoprotein E allele genetic polymorphism meta-analysis 


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Copyright information

© Huazhong University of Science and Technology 2019

Authors and Affiliations

  • Hao Nie
    • 1
  • Yang Hu
    • 1
  • Na Liu
    • 1
  • Ping Zhang
    • 1
  • Gai-gai Li
    • 1
  • Yan-yan Li
    • 1
  • Chao Pan
    • 1
  • Hai-han Yu
    • 1
  • Qian Wu
    • 1
  • Guo-feng Wu
    • 2
    Email author
  • Zhou-ping Tang
    • 1
    Email author
  1. 1.Department of Neurology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Affiliated Hospital of Guizhou Medical UniversityGuiyangChina

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