Association of connexin gene polymorphism with essential hypertension in Kazak and Han Chinese in Xinjiang, China

  • Li-jie Wang (王立杰)
  • Wen-wen Zhang (张文雯)
  • Liang Zhang (张 亮)
  • Wen-yan Shi (石文艳)
  • Ying-zi Wang (王英姿)
  • Ke-tao Ma (马克涛)
  • Wei-dong Liu (刘卫东)
  • Lei Zhao (赵 磊)
  • Li Li (李 丽)
  • Jun-qiang Si (司军强)


Essential hypertension (EH) is affected by both genetic and environmental factors. The polymorphism of connexin (Cx) genes is found associated with the development of hypertension. However, the association of the polymorphism of Cxs with EH has not been investigated. This study aimed to investigate the association of the polymorphism of connexin (Cx) genes Cx37, Cx40, and Cx43 with EH in Kazak and Han Chinese in Xinjiang, China. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) were used to analyze the polymorphism of Cx genes in Kazak and Han EH patients as well as their normotensive controls. The results showed that there were no significant differences in the frequencies of different three genotypes (A/A, A/G, and G/G) and A and G alleles of Cx40 rs35594137 and rs11552588 between EH patients and normotensive controls. However, in Kazak EH patients, the frequencies of three genotypes (A/A, A/G, and G/G) of Cx37 rs1630310 were 24.8%, 47.2% and 28.0%, respectively, which were significantly different from those in Han EH patients. In Han EH patients, the frequencies of the three genotypes (C/C, C/G and G/G) of Cx43 rs1925223 were 6.4%, 35.6% and 58.0%, respectively. Frequencies of the other four genotypes had no statistical differences among Kazak and Han EH patients and their normotensive controls. These results suggest polymorphisms of Cx37 rs1630310 and Cx43 rs1925223 genes may be associated with the pathogenesis of EH. Carrying Cx37 rs1630310-A or Cx43 rs1925223-G genotypes may protect against the development of EH.

Key words

essential hypertension Kazak Chinese Han Chinese connexin genes single nucleotide polymorphism 


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Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Li-jie Wang (王立杰)
    • 1
    • 3
  • Wen-wen Zhang (张文雯)
    • 1
    • 2
  • Liang Zhang (张 亮)
    • 1
    • 2
  • Wen-yan Shi (石文艳)
    • 1
    • 2
  • Ying-zi Wang (王英姿)
    • 2
  • Ke-tao Ma (马克涛)
    • 1
    • 2
  • Wei-dong Liu (刘卫东)
    • 1
    • 2
  • Lei Zhao (赵 磊)
    • 1
    • 2
  • Li Li (李 丽)
    • 1
    • 2
  • Jun-qiang Si (司军强)
    • 1
    • 2
    • 4
    • 5
  1. 1.Department of PhysiologyMedical College of Shihezi UniversityShiheziChina
  2. 2.The Key Laboratory of Xinjiang Endemic and Ethnic DiseasesMedical College of Shihezi UniversityShiheziChina
  3. 3.Department of ICUFirst Affiliated Hospital of Shihezi University School of MedicineShiheziChina
  4. 4.Department of Physiology, School of Basic Medicine, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  5. 5.Department of PhysiologyWuhan University School of Basic Medical SciencesWuhanChina

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