Thirty-eight cases of acute pancreatitis in pregnancy: A 6-year single center retrospective analysis

  • Dong-lin Zhang (张冬林)
  • Yi Huang (黄 毅)
  • Li Yan (严 丽)Email author
  • Amy Phu
  • Xiao Ran (冉 晓)
  • Shu-sheng Li (李树生)


Thirty-eight pregnant inpatients with acute pancreatitis (AP) were retrospectively reviewed from 2006 to 2012 in our hospital. The incidence of pregnancy-associated AP was 2.27‰. Most (78.95%) of the attack occurred in the third trimester. The median of APACHE II score was 6 and severe AP accounted for 31.58% (12 cases). Primary diseases were absent in most cases (57.89%). The most common clinical presentations were abdominal pain (89.47%) and vomiting (68.42%). Pleural effusion and ascites were found only in the third trimester. Elevated white blood cell count, amylase and lipase were commonly found in biochemical examinations. Eleven cases required intensive care in ICU and 21 cases received caesarean section. There were 2 maternal deaths and 12 fetal losses including 4 abortions. It is concluded that AP is a rare entity in pregnancy. The incidence of pancreatitis increases with the gestational age. However, the severity is not necessarily related with the pregnancy trimesters. The diagnosis is based on clinical presentations, laboratory tests and imaging examinations. Although the treatment strategy of a pregnant woman with pancreatitis is similar to the general non-pregnant patient with AP, a multidisciplinary team consisting of gastroenterologist, gastrointestinal surgeon, radiologist, obstetrician, and ICU doctor should be set up.

Key words

acute pancreatitis pregnancy clinical characteristics fetal outcomes 


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Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Dong-lin Zhang (张冬林)
    • 1
  • Yi Huang (黄 毅)
    • 2
  • Li Yan (严 丽)
    • 3
    Email author
  • Amy Phu
    • 4
  • Xiao Ran (冉 晓)
    • 3
  • Shu-sheng Li (李树生)
    • 3
  1. 1.Department of PharmacyHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of NephrologyHuazhong University of Science and TechnologyWuhanChina
  3. 3.Department of ICU, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  4. 4.Department of ICU, Nepean Hospital and Nepean Clinical SchoolUniversity of SydneyPenrithAustralia

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