Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in han Chinese population

  • Lifeng Liu (刘丽凤)
  • Jinjian Yao (姚津剑)
  • Jin Li (里 进)
  • Jinliang Zhang (张金良)
  • Jinling Yu (余金玲)
  • Xiaorui Jiang (姜小瑞)
  • Shuzhen Sun (孙淑珍)
  • Qing Liu (刘 庆)
  • Ying Chang (常 莹)
  • Yongwen He (贺永文)
  • Jusheng Lin (林菊生)


Host genetic, environmental and viral factors are classified as three categories that determine clinical outcomes of hepatitis B virus (HBV) infection. The objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in Rho GTPase-activating protein 24 (ARHGAP24) gene and disease progression of HBV infection in Han Chinese population. These two SNPs were found by our DNA pooling using Affymetrix Genome-Wide Human Mapping SNP6.0 Array in HBV carriers, and verified by using TaqMan 7900HT Sequence Detection System with 758 progressed HBV carriers versus 300 asymptomatic HBV carriers (AsC) in a discovery phase and 971 progressed HBV carriers versus 328 AsC in a replication phase. Multivariable logistic regression revealed that individuals with genotype TT at variant rs346473 displayed remarkable correlations with disease progression of HBV infection both in the discovery phase (OR, 2.693; 95% CI, 1.928–3.760; P=6.2×10−9; additive model) and the replication phase (OR, 1.490; 95% CI, 1.104–2.012; P=9.0×10−3; additive model). These two SNPs were in strong linkage disequilibrium with D′=0.99 and r 2=0.951, and haplotype TT disclosed an increased susceptibility to HBV progression (OR, 1.980; 95% CI, 1.538–2.545; P=8.1×10−8). These findings suggest that polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants underlying the susceptibility of HBV carriers to disease progression.

Key words

ARHGAP24 gene single nucleotide polymorphisms HBV progression 


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Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Lifeng Liu (刘丽凤)
    • 1
    • 2
  • Jinjian Yao (姚津剑)
    • 1
  • Jin Li (里 进)
    • 1
  • Jinliang Zhang (张金良)
    • 2
  • Jinling Yu (余金玲)
    • 1
  • Xiaorui Jiang (姜小瑞)
    • 1
  • Shuzhen Sun (孙淑珍)
    • 1
  • Qing Liu (刘 庆)
    • 1
  • Ying Chang (常 莹)
    • 1
  • Yongwen He (贺永文)
    • 3
  • Jusheng Lin (林菊生)
    • 1
  1. 1.Institute of Liver Disease, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Liaocheng People’s HospitalLiaochengChina
  3. 3.Department of Infection Disease, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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