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Association of polymorphisms in angiotensin II receptor genes with aldosterone-producing adenoma

  • Jinzhi Ouyang (欧阳金芝)
  • Zhun Wu (吴 准)
  • Jinchun Xing (邢金春)
  • Yongji Yan (闫永吉)
  • Guoxi Zhang (张国玺)
  • Baojun Wang (王保军)
  • Hongzhao Li (李宏召)
  • Xin Ma (马 鑫)
  • Xu Zhang (张 旭)Email author
Article

Summary

This study examined the association of polymorphisms in angiotensin II receptor genes (AT 1 R and AT 2 R) with the risk for aldosterone-producing adenoma (APA) in a Chinese Han population. Four polymorphisms including rs5182 (573T/C) in exon 4, rs5186 (1166A/C) in 3′-untranslated region (3′-UTR) in AT 1 R gene and rs5194 (2274G/A) in 3′-UTR, rs1403543 (1675G/A) in intron 1 in AT 2 R gene were detected in 148 APA patients and 192 normal subjects (serving as control) by using a MGB-Taqman probe. The distribution of genotypes of each locus was in accordance with Hardy-Weinberg Equilibrium (HWE) in the APA and control groups (P>0.05). The allele A frequency at rs5194 was significantly higher in the APA group (0.49) than in the control group (0.35) (χ 2=12.08, P=0.001). Subjects with homozygotic genotype AA and heterozygotic genotype GA were at an increased risk for APA as compared to those with GG genotype (OR=2.66, 95% CI=1.45–4.87; OR=1.67, 95% CI=1.02–2.74). Furthermore, rs5194 single-nucleotide polymorphism (SNP) at AT 2 R gene was significantly associated with APA in additive (OR=1.64, 95% CI=1.21–2.20, P=0.001), dominant (OR=1.94, 95% CI=1.23–3.06, P=0.003), and recessive model (OR=2.01, 95% CI=1.17–3.45, P=0.01). It was concluded that rs5194 polymorphism at AT 2 R gene was associated with the risk for APA, which may constitute a genetic marker of APA.

Key words

aldosterone-producing adenoma angiotensinIIreceptor polymorphism 

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Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Jinzhi Ouyang (欧阳金芝)
    • 1
  • Zhun Wu (吴 准)
    • 3
  • Jinchun Xing (邢金春)
    • 3
  • Yongji Yan (闫永吉)
    • 4
  • Guoxi Zhang (张国玺)
    • 5
  • Baojun Wang (王保军)
    • 2
  • Hongzhao Li (李宏召)
    • 2
  • Xin Ma (马 鑫)
    • 2
  • Xu Zhang (张 旭)
    • 2
    Email author
  1. 1.Department of EndocrinologyChinese PLA General HospitalBeijingChina
  2. 2.Department of UrologyChinese PLA General HospitalBeijingChina
  3. 3.Department of Urologythe First Affiliated Hospital of Xiamen UniversityXiamenChina
  4. 4.Department of Urologythe Second Affiliated Hospital of Kunming Medical UniversityKunmingChina
  5. 5.Department of Urologythe First Affiliated Hospital of Gannan Medical UniversityGanzhouChina

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