The role of high-sensitivity C-reactive Protein, interleukin-6 and cystatin C in ischemic stroke complicating atrial fibrillation

  • Ling You (尤 玲)
  • Peihua Wang (汪培华)
  • Jiagao Lv (吕家高)
  • Katherine Cianflone
  • Daowen Wang (汪道文)
  • Chunxia Zhao (赵春霞)
Article

DOI: 10.1007/s11596-010-0558-6

Cite this article as:
You, L., Wang, P., Lv, J. et al. J. Huazhong Univ. Sci. Technol. [Med. Sci.] (2010) 30: 648. doi:10.1007/s11596-010-0558-6

Summary

This study examined the role of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6) and cystatin C in ischemic stroke complicating atrial fibrillation (AF) and the relationship of systemic inflammation with this disease in order to identify AF patients who are at high risk of stroke and need optimal anticoagulant therapy. A total of 103 AF patients, simple (n=75) or complicated by ischemic stroke (n=28), and 112 control subjects were recruited. IL-6 level was detected by using enzyme linked immunosorbent assay. Cystatin C and hsCRP levels were measured by means of a particle-enhanced immunonephelometric assay. The results showed that the AF patients had higher levels of hsCRP (P=0.004), IL-6 (P=0.000), and cystatin C (P=0.000) than control subjects. Plasma hsCRP level was increased in the AF patients with ischemic stroke as compared to the patients with simple AF (P=0.036). The AF patients who had the level of hsCRP exceeding 3.83 mg/L were at a higher risk than those with hsCRP level lower than 3.83 mg/L (P=0.030). After adjusting for other factors, cystatin C remained positively associated with IL-6 (r=0.613) and hsCRP (r=0.488). It was concluded that hsCRP is positively correlated with ischemic stroke complicating AF and may be a risk factor independent of other risk factors for AF. Elevated cystatin C level is also indicative of the increased risk of AF.

Key words

C-reactive protein interleukin-6 cystatin C atrial fibrillation ischemic stroke 

Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Ling You (尤 玲)
    • 1
  • Peihua Wang (汪培华)
    • 1
  • Jiagao Lv (吕家高)
    • 1
  • Katherine Cianflone
    • 2
  • Daowen Wang (汪道文)
    • 1
  • Chunxia Zhao (赵春霞)
    • 1
  1. 1.Department of Cardiovascular Medicine, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Centre de Recherche Laval HospitalUniversity LavalSte-FoyCanada

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