Evaluation of epirubicin-induced cardiotoxicity by two-dimensional strain echocardiography in breast cancer patients
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The value of two-dimensional strain echocardiography for assessing left ventricular regional systolic function in breast cancer patients who were treated with epirubicin was evaluated. A total of 116 breast cancer patients were divided into 3 groups: Thirty-eight patients in group A were given epirubicin (Epi) of 120–340 mg/m2, 42 patients in group B received epirubicin of ≥ 360 mg/m2, and 36 patients after surging without chemotherapy served as the control group C. High frame rate two-dimensional images were recorded from apical long-axis view, four-chamber view, two-chamber view of left ventricle. Peak systolic strain of left ventricular subendocardial myocardium was measured using two-dimensional strain software. The conventional echocardiographic parameters were also obtained. Conventional echocardiography showed there was no significant changes in conventional echocardiographic parameters among the three groups (P>0.05). Two-dimensional strain echocardiography revealed that the peak systolic strain of left ventricular subendocardial myocardium in group A was reduced in some segments as compared with the controls (P<0.05). The peak systolic strain of left ventricular subendocardial myocardium in group B was reduced significantly as compared with group C (P<0.05), but that was reduced in group B just in some of the segments as compared with group A (P<0.05). It was concluded that two-dimensional strain echocardiography could early and sensitively display the effects of epirubicin-induced cardiotoxicity on the systolic function of left ventricular subendocardial myocardium, and early monitor the epirubicin-induced cardiotoxicity.
Key wordsechocardiography epirubicin cardiotoxicity breast cancer subendocardial myocardium two-dimensional strain
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- 4.Hrdina R, Gersl V, Klimtova I, et al. Anthracycline-induced cardiotoxicity. Acta Medica (HradecKralove), 2000,43(3):75–82Google Scholar
- 10.Zekri JM, El-Helw LM, Purohit OP, et al. Epirubicin/vinorelbine adjuvant chemotherapy in young women with breast cancer is associated with preservation of menstrual function. Clin Oncol (R Coll Radiol), 2008,20(7):513–516Google Scholar
- 15.Pan XF, Wang K, Zhao XL, et al. Clinical significance of investigating myocardial transmural heterogeneity by integrated backscatter in patients with chronic ischemic dysfunctional myocardium. Chin J Ultras Med (Chinese), 2005,21(3):175–179Google Scholar
- 20.Bi XJ, Deng YB, Shentu WH, et al. Assessment of left ventricular dyssynchrony in patients with hypertrophic cardiomyopathy by two-dimensional strain echocardiography. Chin J Med Imaging Technol (Chinese), 2008, 24(11):1763–1766Google Scholar
- 21.Tong C, Li CL, Song JL, et al. Assessment of right ventricular free wall longitudinal myocardial deformation using speckle tracking imaging in normal subjects. J Huazhong Univ Sci Technol: Med Health (Chinese), 2008,28(2):194–196Google Scholar
- 25.Jiang ZR, Lv HX, Liu PJ, et al. Echocardiography in assessment of cardiotoxity in breast cancer patients treated with anthracycline. Chin J Med Imaging Technol (Chinese), 2005,21(8):1209–1212Google Scholar