Intracranial hypertension syndrome in systemic lupus erythematosus: Clinical analysis and review of the literature

  • Zheng Xue (薛 峥)
  • Xuezhen Wang (王雪贞)
  • Fei Liu (刘 菲)
  • Shaoxian Hu (胡绍先)
  • Suiqiang Zhu (朱遂强)
  • Suming Zhang (张苏明)
  • Bitao Bu (卜碧涛)


In order to better understand the clinical manifestation of systemic lupus erythematosus (SLE) with intracranial hypertension syndrome (IHS), we analyzed the clinical features and treatment of a typical SLE patient with IHS. SLE is one of the most unpredictable autoimmune diseases involving multiple organ systems that is defined clinically and associated with antibodies directed against cell nuclei. IHS is an uncommon manifestation of neuropsychiatric SLE (NPSLE) and is characterized by an elevated intracranial pressure, papilledema, and headache with occasional abducens nerve paresis, absence of a space-occupying lesion or ventricular enlargement, and normal cerebrospinal fluid chemical and hematological constituents. IHS has been reported in a few sporadic cases in patients with SLE worldwide, but rarely has been reported in China. In this study, a 34-year-old female SLE patient with IHS was reported and pertinent literature reviewed. The clinical presentation, image logical features, and investigatory findings were discussed.

Key words

systemic lupus erythematosus intracranial hypertension syndrome central nervous system clinical analysis 


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Copyright information

© Huazhong University of Science and Technology and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Zheng Xue (薛 峥)
    • 1
  • Xuezhen Wang (王雪贞)
    • 1
  • Fei Liu (刘 菲)
    • 1
  • Shaoxian Hu (胡绍先)
    • 2
  • Suiqiang Zhu (朱遂强)
    • 1
  • Suming Zhang (张苏明)
    • 1
  • Bitao Bu (卜碧涛)
    • 1
  1. 1.Department of Neurology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Rheumatology and Clinical Immunology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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