In vitro chemosensitivity testing of primary and recurrent breast carcinomas and its clinical significance

  • Zhi Li (샮훎)
  • Haiping Song (쯎몣욽)
  • Wenshan He (뫎컄즽)
  • Yuan Tian (쳯풭)
  • Tao Huang (黄 韬)
Article

DOI: 10.1007/s11596-008-0616-5

Cite this article as:
Li, Z., Song, H., He, W. et al. J. Huazhong Univ. Sci. Technol. [Med. Sci.] (2008) 28: 683. doi:10.1007/s11596-008-0616-5

Summary

In this study, in vitro chemosensitivity testing was conducted on primary cultured breast cancer cells from 96 patients with breast cancer, and the results showed that the cells from a few patients with primary breast cancer developed multidrug resistance (MDR) prior to the first chemotherapy exposure. All the cells from the recurrent cancer patients had MDR. The findings suggested that patients having MDR would benefit from high-dose chemotherapy (HDC) regimens. In vitro chemosensitivity screening, which was aimed at improving the therapeutic efficacy and minimizing side effects, helps in choosing individualized treatment for breast cancer.

Key words

chemotherapy breast cancer primary culture in vitro study 

Copyright information

© Huazhong University of Science and Technology and Springer-Verlag GmbH 2008

Authors and Affiliations

  • Zhi Li (샮훎)
    • 1
  • Haiping Song (쯎몣욽)
    • 1
  • Wenshan He (뫎컄즽)
    • 1
  • Yuan Tian (쳯풭)
    • 1
  • Tao Huang (黄 韬)
    • 1
  1. 1.Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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