Association of the platelet membrane glycoprotein I a C807T gene polymorphism with aspirin resistance

  • Su Guanhua  (苏冠华)
  • Wang Zhaohui  (王朝晖)
  • Ding Yanping  (丁艳萍)
  • Liu Xiaoqian  (刘晓倩)
  • Wang Jue  (王珏)
Article

Summary

To explore the correlation between the C807T polymorphism of platelet membrane glycoprotein I a (GP I a) gene and aspirin resistance in Chinese people, 200 patients with high-risk of atherosclerosis took aspirin (100 mg/d) for 7 days. Platelet aggregation function was detected using adenosine diphosphate (ADP) and arachidonic acid (AA) before and after the administration of aspirin. Then the subjects were divided into three groups according to the results of platelet aggregation function: an aspirin resistant (AR) group, an aspirin semi-responder (ASR) group and an aspirin-sensitive (AS) group. Platelet GP I a gene 807CT polymorphism was examined by means of polymerase chain reaction-sequence specific primers (PCR-SSP). The results showed that T allelic frequency in AR group and ASR group were higher that of AS group (P<0.005), and the prevalence of genotypes (TT+TC) of these two groups was significantly higher than that in AS group (P<0.05). Platelet GP I a T allele was significantly associated with aspirin resistance as revealed by multiple logistic regression (OR=3.76, 95% CI: 2.87–9.58). The results suggest that inherited platelet GP I a variations may have an important impact on aspirin resistance and the presence of GP I a T allele may be a marker of genetic susceptibility to aspirin resistance.

Key words

platelet membrane glycoprotein aspirin resistance genetic polymorphism atherosclerosis 

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Copyright information

© Huazhong University of Science and Technology 2008

Authors and Affiliations

  • Su Guanhua  (苏冠华)
    • 1
  • Wang Zhaohui  (王朝晖)
    • 1
  • Ding Yanping  (丁艳萍)
    • 2
  • Liu Xiaoqian  (刘晓倩)
    • 1
  • Wang Jue  (王珏)
    • 3
  1. 1.Department of Cardiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Cardiology, the Third Affiliated HospitalHe’nan University of Science and TechnologyLuoyangChina
  3. 3.The Second Clinical college, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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