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Modulation of interleukin-15-induced suppression of human neutrophil apoptosis by TNFα

  • Liu Xiuping  (刘秀平)
  • Xiong Changyun  (熊长云)
  • Li Chunhong  (李春红)
  • Yang Deguang  (杨德光)
Article

Summary

Human interleukin-15 (IL-15) is a proinflammatory cytokine to suppress neutrophil apoptosis, which is a potential therapeutic agent. The modulatory effect of TNFα was investigated in IL-15-induced suppression of human neutrophil apoptosis. TNFα was shown to reverse the ability of IL-15 to delay neutrophil apoptosis within certain time course. Moreover, this reverse effect by TNFα might be associated with a reduction of the expression of the anti-apoptotic Bcl-Xl protein detected by Western blotting. It is concluded that TNFα can be used to modulate IL-15-induced suppression of neutrophil apoptosis within certain time course.

Key words

neutrophil interleukin-15 TNFα apoptosis Bcl-Xl 

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Copyright information

© Huazhong University of Science and Technology 2007

Authors and Affiliations

  • Liu Xiuping  (刘秀平)
    • 1
  • Xiong Changyun  (熊长云)
    • 2
  • Li Chunhong  (李春红)
    • 3
  • Yang Deguang  (杨德光)
    • 4
  1. 1.College of Life Science and TechnologyHuazhong Universty of Science and TechnologyWuhanChina
  2. 2.Molecular Targets Development ProgramNational Cancer Institute-Frederick National Institutes of Health FrederickUSA
  3. 3.Affiliated Tumor HospitalHarbin Medical UniversityHarbinChina
  4. 4.College of AgricultureNortheast Agricultural UniversityHarbinChina

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