Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

  • Yin Xiaoming  (殷晓明)
  • Tu Ling  (涂玲)
  • Yang Huiqing  (杨慧清)


In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimulated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P<0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P<0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.

Key words

obesity adipocyte adiponectin simvastatin interleukin-6 


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Copyright information

© Huazhong University of Science and Technology 2007

Authors and Affiliations

  • Yin Xiaoming  (殷晓明)
    • 1
  • Tu Ling  (涂玲)
    • 2
  • Yang Huiqing  (杨慧清)
    • 1
  1. 1.Department of Geriatric MedicineAnqing Municipal HospitalAnqingChina
  2. 2.Department of Integration, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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