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Effects of morphine, fentanyl and tramadol on human immune response

  • Liu Zhihen  (刘志恒)
  • Gao Feng  (高峰)
  • Tian Yuke  (田玉科)
Article

Summary

Morphine has been reported to suppress human immune response. We aimed to observe the effects of morphine, fentanyl and tramadol on NF-κB and IL-2 from both laboratory and clinical perspective. Jurkat cells were incubated with ten times clinically relevant concentrations of morphine, fentanyl and tramadol before being stimulated with PMA. NF-κB binding activity and IL-2 levels were measured. In the clinical study, 150 consenting patients were randomized into 3 groups according to the analgesics used in them, namely, group morphine (M), group fentanyl (F) and group tramadol (T). IL-2 was measured preoperatively and 1, 3 and 24 h after operation. Consequently, NF-κB activation was suppressed by morphine and fentanyl but not by tramadol. IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro. In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively. Whereas in group T, IL-2 was unchanged 1 h after operation but was significantly elevated 3 and 24 h after operation. Our results showed that the inhibition of morphine on IL-2 was most probably related to its suppression on NF-κB. Fentanyl had different effects on human immune response in vitro and in vivo. Tramadol may have immune enhancing effect.

Key words

morphine fentanyl tramadol NF-κB IL-2 

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Copyright information

© Huazhong University of Science and Technology 2006

Authors and Affiliations

  • Liu Zhihen  (刘志恒)
    • 1
    • 2
  • Gao Feng  (高峰)
    • 1
  • Tian Yuke  (田玉科)
    • 1
  1. 1.Department of Anesthesiology, Tongji HospitalHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of AnesthesiologyThe Second Hospital in ShenzhenShenzhenChina

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