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Preparation and Characterization of Florfenicol/Chitosan-stearic Acid Polymer Nanomicelle and Its Antibiotic Properties

  • Xiaodan Qi (齐晓丹)
  • Xile Jia
  • Yimin Song (宋益民)
Biomaterials
  • 21 Downloads

Abstract

Amphiphilic CS-SA polymers were prepared using the SA modified by small molecule water-soluble chitosan, and CS-SA nanomicelles and FF/CS -SA nanomicelles were prepared by using CSSA polymers as the material with dialysis-ultrasound method. CS-SA polymers, CS-SA nanomicelles, and FF/CS-SA nanomicelles were characterized by FT-IR, TGA, and SEM. Results showed that the SA was grafted to the amino of CS by amide bond. CS-SA nanomicelles and FF/CS-SA nanomicelles were spherical, smooth without fold. The influence of different molar ratio of FF to CS-SA polymers on the encapsulation efficiency and drug-loading rate determined the best molar ratio that was 1:1.09. In vitro release experiments, drug release performance study found that hydrophobic drug releasing from FF/CS-SA nanomicelles presented sustained-release. In vitro bacteriostasis experiments, when the concentration was higher than 4.98 mg/mL, FF/CS-SA nanomicelles had antibacterial action and a positive correlation with concentration. The results revealed that amphiphilic chitosan derivative nanomicelles were carriers with broad prospects, increasing solubility of hydrophobic drugs and presenting sustained release for hydrophobic drugs, which provided a new research idea for drug delivery and targeted drug delivery of hydrohobic drugs.

Key words

nanomicelle water-soluble chitosan hydrophobic drug antibacterial activity 

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Copyright information

© Wuhan University of Technology and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xiaodan Qi (齐晓丹)
    • 1
    • 2
  • Xile Jia
    • 1
  • Yimin Song (宋益民)
    • 1
  1. 1.Department of Pharmaceutical EngineeringQingdao University of Science & TechnologyQingdaoChina
  2. 2.E E-Jiao Co., Ltd.LiaochengChina

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