Chitosan—L- lactic acid scaffold for the regeneration of peripheral nerve and its NGF release properties

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Abstract

Chitosan—L-lactic acid composite scaffold for the regeneration of peripheral nerve is obtained by grafting L-lactic acid onto the amino groups in chitosan with combined vacuum freezer drier. The composite scaffold was characterized by ATR-FTIR and SEM. The scaffold has a better graft efficiency and has a dense inner layer and a loose outer layer with porous structure, and the pore size is about 100 µm. The NGF release properties of the scaffold were investigated. The experimental results showed that, at the 1st day, 15.2 ng of NGF on average was released from the scaffold. From day 2 to day 10, the release rate obviously slowed down and 1.64 ng of NGF was released on average every day. After 10 days, the release rate was slower and 10.3 ng of NGF was released on average every day. After 60 days, NGF could also maintained a certain concentration. These properties show that the scaffold is a better carrier for NGF which can be more advantageous to the regeneration of the damaged peripheral nerve. As a result, this composite scaffold would be an ideal candidate for the regeneration of damaged peripheral nerve.

Key words

chitosan L-lactic acid peripheral nerve NGF release properties 
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Copyright information

© Wuhan University of Technology and Springer Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Pharmaceutical Engineering, School of Chemical EngineeringWuhan University of TechnologyWuhanChina
  2. 2.Biomedical Materials and Engineering Research CenterWuhan University of TechnologyWuhanChina

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