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Ionics

, Volume 24, Issue 3, pp 833–843 | Cite as

Determination of tramadol in pharmaceutical products and biological samples using a new nanocomposite carbon paste sensor based on decorated nanographene/tramadol-imprinted polymer nanoparticles/ionic liquid

  • Hasan Bagheri
  • Ali Shirzadmehr
  • Mosayeb Rezaei
  • Hosein Khoshsafar
Original Paper

Abstract

In the present research, design and construction of a development potentiometric sensor based on a newly nanosensing layer for the sensitive determination of tramadol in various real samples were suggested. The proposed nanosensing layer was fabricated with the incorporation of a synthesized tramadol-imprinted polymer nanoparticles “as an efficient sensing agent” into the carbon paste matrix composed of graphite powder, decorated graphene nanosheets with silver nanoparticles, and a typically ionic liquid as the conductive pasting binder. The detection limit and the linear range of this study were found to be 2.04 × 10−9 and 3.50 × 10−9 to 1.00 × 10−2 M with a Nernstian slope of 59.85 ± 0.13 mV decade−1, respectively. The presented modified carbon paste sensor was successfully applied for the determination of tramadol in pharmaceutical and biological samples.

Keywords

Tramadol-imprinted polymer Potentiometric sensor Decorated nanographene Silver nanoparticles Ionic liquid 

Notes

Acknowledgements

The authors wish to thank the Young Researchers and Elite Club at the Islamic Azad University, Iran. And also, the authors thank the Researches and Technology Council, Baqiyatallah University of Medical Sciences, Tehran, Iran, for the support.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Hasan Bagheri
    • 1
  • Ali Shirzadmehr
    • 2
  • Mosayeb Rezaei
    • 3
  • Hosein Khoshsafar
    • 3
  1. 1.Chemical Injuries Research CenterBaqiyatallah University of Medical SciencesTehranIran
  2. 2.Young Researchers and Elite Club, Sari BranchIslamic Azad UniversitySariIran
  3. 3.Young Researchers and Elite Club, Hamedan BranchIslamic Azad UniversityHamedanIran

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