Exposure to Mozart music reduces cognitive impairment in pilocarpine-induced status epilepticus rats
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Patients with temporal lobe epilepsy (TLE) often display cognitive deficits. However, current epilepsy therapeutic interventions mainly aim at how to reduce the frequency and degree of epileptic seizures. Recovery of cognitive impairment is not attended enough, resulting in the lack of effective approaches in this respect. In the pilocarpine-induced temporal lobe epilepsy rat model, memory impairment has been classically reported. Here we evaluated spatial cognition changes at different epileptogenesis stages in rats of this model and explored the effects of long-term Mozart music exposure on the recovery of cognitive ability. Our results showed that pilocarpine rats suffered persisting cognitive impairment during epileptogenesis. Interestingly, we found that Mozart music exposure can significantly enhance cognitive ability in epileptic rats, and music intervention may be more effective for improving cognitive function during the early stages after Status epilepticus. These findings strongly suggest that Mozart music may help to promote the recovery of cognitive damage due to seizure activities, which provides a novel intervention strategy to diminish cognitive deficits in TLE patients.
KeywordsStatus epilepticus Mozart music Morris water maze Cognitive damage
This work was supported by the National Natural Science Foundation of China (No. 81371636, 81071222, and 61201278), the 111 Project (B12027) and the PCSIRT project. This study was also funded by the Scientific and Technological Research program of Chongqing Municipal Education Commission (No. KJ121309).
- Lin L-C, Ouyang C-S, Chiang C-T et al (2014) Listening to Mozart K.448 decreases electroencephalography oscillatory power associated with an increase in sympathetic tone in adults: a post-intervention study. J R Soc Med Open 5(10):1–7Google Scholar