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NanoEthics

, Volume 8, Issue 1, pp 1–17 | Cite as

Metaphors in Nanomedicine: The Case of Targeted Drug Delivery

  • Bernadette Bensaude Vincent
  • Sacha Loeve
Original Paper

Abstract

The promises of nanotechnology have been framed by a variety of metaphors, that not only channel the attention of the public, orient the questions asked by researchers, and convey epistemic choices closely linked to ethical preferences. In particular, the image of the ‘therapeutic missile’ commonly used to present targeted drug delivery devices emphasizes precision, control, surveillance and efficiency. Such values are highly praised in the current context of crisis of pharmaceutical innovation where military metaphors foster a general mobilization of resources from multiple fields of cutting-edge research. The missile metaphor, reminiscent of Paul Ehrlich’s ‘magic bullet’, has framed the problem in simple terms: how to deliver the right dose in the right place at the right moment? Chemists, physicists and engineers who design multi-functional devices operating in vitro can think in such terms, as long as the devices are not actually operating through the messy environment of the body. A close look at what has been done and what remains to be done suggests that the metaphor of the “therapeutic missile” is neither sufficient, nor even necessary. Recent developments in nanomedicine suggest that therapeutic efficacy cannot be obtained without negotiating with the biological milieu and taking advantage of what it affords. An ‘oikological’ approach seems more appropriate, more heuristic and more promising than the popular missile. It is based on the view of organism as an oikos that has to be carefully managed. The dispositions of nanocapsules have to be coupled with the affordances of the environment. As it requires dealing with nanoparticles as relational entities (defined by their potential for interactions) rather than as stable substances (defined by intrinsic properties) this metaphor eventually might well change research priorities in nanotechnology in general.

Keywords

Nanomedicine Pharmacology Nanorobot Magic bullet Dispositions Affordances Efficiency Efficacy 

Notes

Acknowledgments

We are grateful to Patrick Couvreur, Florence Gazeau, Ania Servant, Cyril Bussy, and Brigitte Nerlich.

Funding Sources

The research for this paper has been conducted by the authors with the help of ANR-project Nano-2E ANR-09-NANO-001-02.

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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.CETCOPRAParisFrance
  2. 2.Université Paris 1ParisFrance
  3. 3.IUFParisFrance

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