NanoEthics

, Volume 4, Issue 3, pp 205–214 | Cite as

Freitas on Disease in Nanomedicine: Implications for Ethics

Original Paper

Abstract

This paper critically examines the volitional normative model of disease and its underlying nanotechnologic vision of medicine both defended by Robert Freitas. Having provided an account of this vision, we explicate the highlight of the model, which is a concept of disease based on individual values and preferences. The model’s normative positions are then critiqued based on our argument that the epistemic basis of Freitas’s vision of nanotechnologic medicine and, by extension, of his volitional normative model of disease is scientifically flawed. An ethical and social critique of the model is then conducted on the basis of the model’s implicit ethical underpinnings. We argue that Freitas fails to justify the normativity of his model by not addressing the ethical issues that permeate it, one of which is the question of responsibility regarding the development of medical nanotechnology and the practice of new forms of medicine such as the one he envisions. We conclude that, due to its radically individualistic position, the model implies an unjustified view of nanoethics and relegates this field of ethics to the periphery of discussions of nanomedicine.

Keywords

Chromosome replacement therapy Freitas Molecular reference structures Molecular technologic medicine Nanoethics Nanomedicine Nanotechnologic medicine Nanotechnology Volitional normative model of disease 

Notes

Acknowledgments

This research was supported, in part, by a National Science Foundation Sub-Grant from the Center of Nanoengineering of Polymeric Biomedical Devices at Ohio State University.

The authors wish to thank Neocles Leontis for his feedback on their biological account of gene expression/protein synthesis and two anonymous reviewers of the journal for their encouragement and valuable criticism.

References

  1. 1.
    Abplanalp J (1983) Premenstrual syndrome: a selective review. In: Golub S (ed) Lifting the curse of menstruation: a feminist appraisal of the influence of menstruation on women’s lives. The Haworth, New York, p 107Google Scholar
  2. 2.
    Agich GJ (1983) Disease and value: a rejection of the value–neutrality thesis. Theor Med 4:27–41CrossRefGoogle Scholar
  3. 3.
    Agich GJ (1997) Toward a pragmatic theory of disease. In: Humber JM, Almeder RF (eds) What is disease? Humana, Totowa, pp 221–246Google Scholar
  4. 4.
    Altshuler D, Daly MJ, Lander ES (2008) Genetic mapping in human disease. Science 322:881–888CrossRefGoogle Scholar
  5. 5.
    Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JL (2005) Host–bacterial mutualism in the human intestine. Science 307:1915–1920CrossRefGoogle Scholar
  6. 6.
    Bainbridge WS et al (2006) Ethical considerations in the advance of nanotechnology. In: Foster LE (ed) Nanotechnology: science, innovation and opportunity. Prentice Hall PTR, Upper Saddle River, pp 233–245Google Scholar
  7. 7.
    Bawa R, Johnson S (2007) The ethical dimensions of nanomedicine. Med Clin North Am 91:881–887CrossRefGoogle Scholar
  8. 8.
    Bayer R (1981) Homosexuality and American psychiatry: the politics of diagnosis. Basic Books, New YorkGoogle Scholar
  9. 9.
    Boenink M (2009) Molecular medicine and concepts of disease: the ethical value of a conceptual analysis of emerging biomedical technologies. Med Health Care Philos 13:11–23CrossRefGoogle Scholar
  10. 10.
    Boorse C (1977) Health as a theoretical concept. Philos Sci 44:542–573CrossRefGoogle Scholar
  11. 11.
    Breggin L, Carothers L (2006) Governing uncertainty: the nanotechnology environmental, health, and safety challenge. Columbia J Environ Law 31:285–329Google Scholar
  12. 12.
    Brune H, Ernst H, Grunwald A et al (2006) Nanotechnology: assessment and perspectives (ethics of science and technology assessment). Springer – Verlag, BerlinGoogle Scholar
  13. 13.
    deVito S (2000) On the value–neutrality of the concepts of health and disease: unto the breach again. J Med Philos 25:539–567CrossRefGoogle Scholar
  14. 14.
    Dupuy J-P (2007) Some pitfalls in the philosophical foundations of nanoethics. J Med Philos 32:237–261CrossRefGoogle Scholar
  15. 15.
    Engelhardt HT Jr (1981) The concepts of health and disease. In: Caplan AL, Engelhardt HT Jr, McCartney JJ (eds) Concepts of health and disease: interdisciplinary perspectives. Addison-Wesley, Houston, pp 31–45Google Scholar
  16. 16.
    Feynman R (1960) There’s plenty of room at the bottom. Engineering and Science 23:22–36Google Scholar
  17. 17.
    Freitas AR Jr (2005) What is nanomedicine? Nanomed Nanotechnol Biol Med 1:2–9CrossRefGoogle Scholar
  18. 18.
    Freitas AR Jr (2007) Personal choice in the coming era of nanomedicine. In: Allhoff F, Lin P, Moor J, Weckert J (eds) Nanoethics: the ethical and social implications of nanotechnology. John Wiley & Sons, Inc., Hoboken, pp 161–172Google Scholar
  19. 19.
    Khushf G (2007) An agenda for future debate on concepts of health and disease. Med Health Care Philos 10:19–27CrossRefGoogle Scholar
  20. 20.
    Lenk C, Biller-Andorno N (2007) Nanomedicine – emerging or re-emerging ethical issues? Med Health Care Philos 10:173–184CrossRefGoogle Scholar
  21. 21.
    Minard ME, Jain AK, Barton MC (2009) Analysis of epigenetic alterations to chromatin during development. Genesis 47:559–572CrossRefGoogle Scholar
  22. 22.
    National Research Council of the National Academies (2009) Committee for review of the federal strategy to address environmental, health, and safety research needs for engineered nanoscale materials. Review of the federal strategy for nanotechnology–related environmental, health, and safety research. The National Academies Press, Washington, DCGoogle Scholar
  23. 23.
    Nordenfelt L (2007) The concepts of health and illness revisited. Med Health Care Philos 10:5–10CrossRefGoogle Scholar
  24. 24.
    Offman A, Kleinplatz PJ. (2004) Does PMDD belong in the DSM? Challenging the medicalization of women’s bodies. The Canadian Journal of Human Sexuality 13(1):17–24Google Scholar
  25. 25.
    Richardson JTE (2004) The premenstrual syndrome: a brief history. In: Caplan AL, McCartney JJ, Sisti DA (eds) Health, disease, and illness: concepts in medicine. Georgetown University Press, Washington, DC, pp 176–186Google Scholar
  26. 26.
    Roco MC (2003) Nanotechnology: convergence with modern biology and medicine. Curr Opin Biotechnol 14:337–346CrossRefGoogle Scholar
  27. 27.
    Roco MC (2005) Converging technologies: nanotechnology and biomedicine. In: Malsch NH (ed) Biomedical nanotechnology. Taylor & Francis, London, pp xi–xixGoogle Scholar
  28. 28.
    Roco MC, Bainbridge WS (2003) Converging technologies for improving human performance: nanotechnology, biotechnology, information technology and cognitive science. Kluwer Academic, DordrechtGoogle Scholar
  29. 29.
    Sadler JZ (2005) Values and psychiatric diagnosis. Oxford University Press, OxfordGoogle Scholar
  30. 30.
    Spitzer RL (1981) The diagnostic status of homosexuality in DSM–III: a reformulation of the issues. Am J Psychiatry 138:210–215Google Scholar
  31. 31.
    Thomas K, Sayre P (2005) Research strategies for safety evaluation of nanomaterials, Part I: evaluating the human health implications of exposure to nanoscale materials. Toxicol Sci 87:316–321CrossRefGoogle Scholar
  32. 32.
    Tucker BP (1998) Deaf culture, cochlear implants, and elective disability. Hastings Cent Rep 28:6–14Google Scholar
  33. 33.
    Watson J et al (2008) Molecular biology of the gene, 6th edn. Pearson/Benjamin Cummings, San FranciscoGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Bowling Green State UniversityBowling GreenUSA

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