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Ionenkanäle und Nieren- und Hochdruckerkrankungen

Ion channels in relation to renal and hypertensive diseases

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Der Nephrologe Aims and scope

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Zusammenfassung:

Die Funktion der Niere wird ganz wesentlich durch die Aktivität von Ionenkanälen und Ionentransportern bestimmt. Auf dem Gebiet der Ionenkanalforschung hat es in den vergangenen zehn Jahren einige herausragende Neuentdeckungen gegeben, die das Feld der Kanalopathien, also Erkrankungen die auf die Fehlfunktion von einzelnen Ionenkanälen zurückzuführen sind, ganz neu beleuchtet haben und gleichzeitig auch die pathophysiologische Bedeutung von Ionenkanälen für multifaktorielle Erkrankungen aufzeigten. Diese Entwicklung betrifft insbesondere auch das nephrologische Forschungsgebiet, bei der Arbeiten zu Ionenkanälen nicht nur Fortschritte im Verständnis der physiologischen Nierenfunktion, sondern besonders auch bei der Aufklärung von Pathomechanismen von spezifischen Nierenerkrankungen ergeben haben. Anhand von fünf Nieren- und Hochdruckerkrankungen wird die Art und Weise, in der Ionenkanäle Krankheiten auslösen können, dargestellt.

Abstract

Renal function is essentially determined by ion channels and ion transporters. Several outstanding discoveries have been made in the past 10 years in the field of research on ion channels. These insights have shed new light on ion channelopathies, i.e., disorders due to dysfunction of individual ion channels, and at the same time pinpointed the pathophysiological significance of ion channels for multifactorial diseases. This development also applies particularly to the area of nephrological research where studies on ion channels have not only led to progress in understanding physiological renal function but have also aided in elucidating the pathomechanisms of specific kidney diseases. Illustrated on the basis of five renal and hypertensive diseases, the manner in which ion channels can cause disease is described.

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Authors and Affiliations

  1. Klinik für Innere Medizin und Nephrologie, Philipps-Universität Marburg, Baldingerstraße, 35033, Marburg, Deutschland

    I. Grgic, R. Köhler &  J. Hoyer

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  1. I. Grgic
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  2. R. Köhler
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  3. J. Hoyer
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Correspondence to J. Hoyer.

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Grgic, I., Köhler, R. & Hoyer, J. Ionenkanäle und Nieren- und Hochdruckerkrankungen. Nephrologe 3, 358–365 (2008). https://doi.org/10.1007/s11560-008-0225-0

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  • DOI: https://doi.org/10.1007/s11560-008-0225-0

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