Der Nephrologe

, Volume 3, Issue 3, pp 222–228 | Cite as

Glomeruläre Läsionen bei Transplantatabstoßung

Leitthema
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Zusammenfassung

Abstoßungsreaktionen sind die häufigste Ursache für ein Transplantatversagen nach Nierentransplantation. Glomeruläre Läsionen finden sich dabei relativ selten. Die thrombotische Mikroangiopathie und die Transplantatglomerulitis treten früh nach Transplantation auf, die Transplantatglomerulopathie bildet sich in der Regel erst nach längerer Zeit aus. Die morphologischen Befunde, in deren Zentrum ein Endothelschaden steht, und mögliche pathogenetische Mechanismen werden diskutiert.

Schlüsselwörter

Nierentransplantation Thrombotische Mikroangiopathie Transplantat-Glomerulitis Transplantat-Glomerulopathie Endothelschaden 

Glomerular lesions in kidney transplant rejection

Abstract

Acute and chronic rejection is the most common cause of graft failure after kidney transplantation. Glomerular lesions are relatively rare. Thrombotic microangiopathy and transplant glomerulitis occur early after transplantation, whereas transplant glomerulopathy may develop later. The common theme of these diverse lesions is endothelial damage. The morphological findings and pathogenetic mechanisms are discussed.

Keywords

Kidney transplantation Thrombotic microangiopathy Transplant glomerulitis Transplant glomerulopathy Endothelial damage 

Notes

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  1. 1.Institut für PathologieUniversitätsspital BaselBaselSchweiz
  2. 2.Klinik für Nephrologie und TransplantationsimmunologieUniversitätsspital BaselBaselSchweiz

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