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Auditory display for fluorescence-guided open brain tumor surgery

  • David BlackEmail author
  • Horst K. Hahn
  • Ron Kikinis
  • Karin Wårdell
  • Neda Haj-Hosseini
Original Article

Abstract

Purpose

Protoporphyrin (PpIX) fluorescence allows discrimination of tumor and normal brain tissue during neurosurgery. A handheld fluorescence (HHF) probe can be used for spectroscopic measurement of 5-ALA-induced PpIX to enable objective detection compared to visual evaluation of fluorescence. However, current technology requires that the surgeon either views the measured values on a screen or employs an assistant to verbally relay the values. An auditory feedback system was developed and evaluated for communicating measured fluorescence intensity values directly to the surgeon.

Methods

The auditory display was programmed to map the values measured by the HHF probe to the playback of tones that represented three fluorescence intensity ranges and one error signal. Ten persons with no previous knowledge of the application took part in a laboratory evaluation. After a brief training period, participants performed measurements on a tray of 96 wells of liquid fluorescence phantom and verbally stated the perceived measurement values for each well. The latency and accuracy of the participants’ verbal responses were recorded. The long-term memorization of sound function was evaluated in a second set of 10 participants 2–3 and 7–12 days after training.

Results

The participants identified the played tone accurately for 98% of measurements after training. The median response time to verbally identify the played tones was 2 pulses. No correlation was found between the latency and accuracy of the responses, and no significant correlation with the musical proficiency of the participants was observed on the function responses. Responses for the memory test were 100% accurate.

Conclusion

The employed auditory display was shown to be intuitive, easy to learn and remember, fast to recognize, and accurate in providing users with measurements of fluorescence intensity or error signal. The results of this work establish a basis for implementing and further evaluating auditory displays in clinical scenarios involving fluorescence guidance and other areas for which categorized auditory display could be useful.

Keywords

Fluorescence-guided resection (FGR) Spectroscopy 5-Aminolevulinic acid (5-ALA) Protoporphyrin (PpIX) Surgical navigation Neurosurgery Human–computer interaction User interfaces Sonification LabVIEW 

Notes

Acknowledgements

The authors would like to thank Johan Richter, neurosurgeon at the Department of Neurosurgery in Linköping University and the participants for feedback on the sound system.

Funding   The study was supported by Swedish Childhood Cancer foundation (Grant No. MT 2013-0043), the Cancer network at Linköping University (LiU-cancer), and National Institutes of Health Grants P41 EB015902, P41 EB015898, R01EB014955, and U24CA180918.

Compliance with ethical standards

Conflict of interest

The authors state that they have no conflict of interest.

Ethical approval

No ethical approval is required, as the study was not a type that could affect the subjects physically or psychologically. Data used in Fig. 1 are from a study with ethical approval described in [5].

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

Supplementary material 1 (mp4 5384 KB)

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Copyright information

© CARS 2017

Authors and Affiliations

  1. 1.Medical Image ComputingUniversity of BremenBremenGermany
  2. 2.Jacobs UniversityBremenGermany
  3. 3.Fraunhofer MEVISBremenGermany
  4. 4.Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  5. 5.Department of Biomedical EngineeringLinköping UniversityLinköpingSweden

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